| 产品标题 |
产品货号 |
产品规格 |
厂家 |
| Erlotinib hydrochloride - OSI 774 | Axon 1128
CAS [183319-69-9]
MF C22H23N3O4.HClMW 429.90
Purity:
99%
Soluble in DMSO
Description
EGFR inhibitor; Erlotinib inhibits EGFR tyrosine kinase autophosphorylation by inhibition of the intracellular domain. Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl
References
Certificates
Categories
Extra info
J.R. Johnson et al. Approval Summary for Erlotinib for Treatment of Patients with Locally Advanced or Metastatic Non–Small Cell Lung Cancer after Failure of at Least One Prior Chemotherapy Regimen. Clin. Can. Res. 2005, 11, 6414-6421.
J. Porter et al. A dose escalation and pharmacokinetic (PK) trial of weekly docetaxel combined with daily erlotinib in adult cancer patients. J. Clin. Oncol.2004, 22, 14S, 2119.
Certificate of Analysis
Material Safety Data Sheet
Angiogenesis
Cell Signaling & Oncology
EGFR
JAK-STAT
RTK class I; EC 2.7.10.1
EGFR tyrosine kinase inhibitor
Chemical name
[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine hydrochloride
Parent CAS No.
[183321-74-6]
Order
Size
Unit Price
Stock
10 mg
€70.00
In Stock | | axonmedchem |
| Gefitinib - ZD 1839 | Iressa | Axon 1393
CAS [184475-35-2]
MF C22H24ClFN4O3MW 446.90
Purity:
99%
Soluble in DMSO
Description
Selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor
References
Certificates
Categories
Extra info
G Blackledge, S Averbuch. Gefitinib ('Iressa', ZD1839) and new epidermal growth factor receptor inhibitors. Br. J. Cancer 2004, 90(3), 566-72.
JG Paez et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004, 304(5676), 1497-500.
Certificate of Analysis
Material Safety Data Sheet
Angiogenesis
Cell Signaling & Oncology
EGFR
JAK-STAT
RTK class I; EC 2.7.10.1
EGFR tyrosine kinase inhibitor
Chemical name
N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Parent CAS No.
[184475-35-2]
Order
Size
Unit Price
Stock
10 mg
€70.00
In Stock | | axonmedchem |
| Tolterodine L-tartrate - PNU 200583E | Axon 2049
CAS [124937-52-6]
MF C22H31NO.C4H6O6MW 475.57
Purity:
100%
Optical purity:
Optically pure
Soluble in water and DMSO
Description
Potent and selective muscarinic receptor (mAChR) antagonist (Ki = 3.3 nM; non-selective for subtypes M1-M5); an antimuscarinic drug
References
Certificates
Categories
Extra info
L Nilvebrant et al. Tolterodine - a new bladder-selective antimuscarinic agent. Eur. J. Pharmacol. 1997, 327, 195-207.
P. Abrams et al. Tolterodine, a new antimuscarinic agent: as effective but better tolerated than oxybutynin in patients with an overactive bladder. Br. J. Urol. 1998, 81, 801–810.
Certificate of Analysis
Material Safety Data Sheet
Cardiovascular
CNS
CHRM3
CHRM4
CHRM1
CHRM5
A18
Pfizer Licensed Products
Muscarinic receptor (mAChR) antagonist
Chemical name
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate
Source information
Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.
Parent CAS No.
[124937-51-5]
Order
Size
Unit Price
Stock
10 mg
€90.00
In Stock | | axonmedchem |
| VU 0365114 | Axon 1943
CAS [1208222-39-2]
MF C22H14F3NO3MW 397.35
Purity:
99%
Soluble in DMSO and Ethanol
Description
Selective positive allosteric modulator (PAM) of M5 muscarinic acetylcholine receptor (mAChR), with EC50 = 2.7 µM for M5 and >30 µM for M1–M4 subtypes
References
Certificates
Categories
Extra info
TM Bridges et al. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg. Med. Chem. Lett. 2010, 20(19), 5617.
Structure-activity relationships for a series of M5 muscarinic receptor modulators. by Rao, Paluri Sai Shantanu, Pharm.D., The University of Toledo, Dissertations & Theses 2011, P/N 3489809.
Certificate of Analysis
Material Safety Data Sheet
CNS
CHRM5
A18
Selective PAM of M5 mAChR (CHRM5)
Chemical name
1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione
Parent CAS No.
[1208222-39-2]
Order
Size
Unit Price
Stock
10 mg
€115.00
In Stock | | axonmedchem |
| VU 0255035 | Axon 1787
CAS [1135243-19-4]
MF C18H20N6O3S2MW 432.52
Purity:
99%
Soluble in DMSO
Description
Highly selective antagonist of M1 muscarinic acetylcholine receptor (mAChR) (Ki=14.87 nM)
References
Certificates
Categories
Extra info
DJ Sheffler et al. A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol. Pharmacol. 2009, 76(2), 356-368.
Certificate of Analysis
Material Safety Data Sheet
CNS
CHRM1
A18
Selective M1 mAChR Antagonist
Chemical name
N-(3-oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide
Parent CAS No.
[1135243-19-4]
Order
Size
Unit Price
Stock
10 mg
€120.00
In Stock | | axonmedchem |
| TD52 | Axon 2700
CAS [1798328-24-1]
MF C24H16N4MW 360.41
Purity:
99%
Soluble in DMSO
Description
The CIP2A inhibitor TD52 had more potent apoptotic effects than erlotinib (Axon 1128) in HCC cells (IC50 values of 0.9, 0.9, 0.8 and 1.2 μM in HA22T, Hep3B, PLC5 and Sk-Hep1 cell lines, respectively). Also, CIP2A-dependent p-Akt downregulation mediates TD52-induced apoptosis in TNBC. TD52-induced tumor inhibition was associated with reactivation of PP2A and downregulation of CIP2A and p-Akt in vivo.
KEYWORDS: TD52 | supplier | CIP2A inhibitor | TD 52 | TD-52 | CAS [1798328-24-1] | PP2A | CIP2A | Inhibitor | Proteins | p90 | KIAA1524 | HCC | TNBC | | axonmedchem |
| VU 0238429 | Axon 1786
CAS [1160247-92-6]
MF C17H12F3NO4MW 351.28
Purity:
99%
Soluble in DMSO and Ethanol
Description
Highly selective positive allosteric modulator (PAM) of M5 muscarinic acetylcholine receptor (mAChR)
References
Certificates
Categories
Extra info
TM Bridges et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J. Med. Chem. 2009, 52(11), 3445–3448.
PJ Conn et al. Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol. Sci. 2009, 30(3), 148–155.
TM Bridges et al. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg. Med. Chem. Lett. 2010, 20(19), 5617.
Certificate of Analysis
Material Safety Data Sheet
CNS
CHRM5
A18
Selective PAM of M5 mAChR (CHRM5)
Chemical name
1-(4-methoxybenzyl)-5-(trifluoromethoxy)indoline-2,3-dione
Parent CAS No.
[1160247-92-6]
Order
Size
Unit Price
Stock
10 mg
€105.00
In Stock | | axonmedchem |
| VU 0357017 hydrochloride | Axon 1703
CAS [1135242-13-5]
MF C18H27N3O3.HClMW 369.89
Purity:
100%
Soluble in water and DMSO
Description
Hilghly selective positive allosteric modulator (PAM) of M1 muscarinic acetylcholine receptor (mAChR)
References
Certificates
Categories
Extra info
EP Lebois et al. Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M1 Receptor Function in the Central Nervous System. ACS Chem. Neurosci. 2010, 1(2), 104–121.
TM Bridges et al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg. Med. Chem. Lett. 2010, 20(2), 1972-1975.
Certificate of Analysis
Material Safety Data Sheet
CNS
CHRM1
A18
PAM of M1 mAChR
Chemical name
ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride
Parent CAS No.
[1135681-23-0]
Order
Size
Unit Price
Stock
10 mg
€115.00
In Stock | | axonmedchem |
| MDL 201012 | Axon 1679
CAS [136722-45-7]
MF C19H25NO2MW 299.41
Purity:
98%
Soluble in DMSO
Description
Selective M3 muscarinic receptor antagonist; orally active antimuscarinic agent
References
Certificates
Categories
Extra info
DL Reynolds et al. Determination of MDL 201,012 at femtomole/millilitre levels in human plasma by liquid chromatography with electrochemical detection. Biomed Chromatogr. 1992, 6(6), 295-9.
JP Carter et al. Analogues of oxybutynin. Synthesis and antimuscarinic and bladder activity of some substituted 7-amino-1-hydroxy-5-heptyn-2-ones and related compounds. J. Med. Chem. 1991, 34(10), 3065-74.
Certificate of Analysis
Material Safety Data Sheet
Cardiovascular
CNS
Diabetes & Metabolism
CHRM3
A18
Muscarinic M3 antagonist
Chemical name
1-cyclobutyl-7-(dimethylamino)-1-hydroxy-1-phenylhept-5-yn-2-one
Parent CAS No.
[136722-45-7]
Order
Size
Unit Price
Stock
10 mg
€110.00
In Stock | | axonmedchem |
| VU 0152100 - VU 152100 | Axon 1483
CAS [409351-28-6]
MF C18H19N3O2SMW 341.43
Purity:
99%
Soluble in DMSO
Description
Positive allosteric modulator of M4 muscarinic acetylcholine receptor (mAChR)
References
Certificates
Categories
Extra info
AE Brady et al. Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Ratss. J. Pharmacol. Exp. Ther. 2008, 327(3), 941–953.
CM Jones. M4 Positive Allosteric Modulators For The Treatment Of Schizophrenia. Grant 1R01MH086601-01 from National Institute Of Mental Health.
P Jeffrey Conn et al. Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends in Pharmacological Sciences 2009, 30(3), 148-155.
Certificate of Analysis
Material Safety Data Sheet
CNS
CHRM4
A18
PAM of M4 mAChR
Chemical name
3-Amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 4-methoxy-benzylamide
Parent CAS No.
[409351-28-6]
Order
Size
Unit Price
Stock
5 mg
€85.00
In Stock | | axonmedchem |
| Zamifenacin fumarate - UK 76654 | Axon 1273
CAS [127308-98-9]
MF C31H33NO7MW 531.60
Purity:
99%
Optical purity:
>98% ee
Soluble in DMSO and Ethanol
Description
Selective M3 muscarinic receptor antagonist
References
Certificates
Categories
Extra info
LA Houghton et al. Zamifenacin (UK-76,654), a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome. Aliment. Pharmacol. Ther, 1997, 11(3), 561-568.
Certificate of Analysis
Material Safety Data Sheet
Cardiovascular
CNS
Diabetes & Metabolism
CHRM3
A18
Muscarinic M3 antagonist
Chemical name
(R)-3-Benzhydryloxy-1-(2-benzo[1,3]dioxol-5-yl-ethyl)-piperidine fumarate
Parent CAS No.
[127308-82-1]
Order
Size
Unit Price
Stock
10 mg
€115.00
In Stock | | axonmedchem |
| CDDO - Bardoxolone | RTA 401 | Axon 1950
CAS [218600-44-3]
MF C31H41NO4MW 491.66
Purity:
98%
Soluble in DMSO
Description
A potent multifunctional anti-tumor agent; CDDO induces apoptosis in vitro in malignant cells through both intrinsic and extrinsic pathways, and it controls cellular differentiation, apoptosis, and growth inhibition by serving as a ligand for the transcription factor PPAR-γ; highly active inhibitor of nitric oxide production in mouse macrophages; it shows antiinflammatory activity against thioglycollate-interferon-gamma-induced mouse peritonitis
* Parent acid of CDDO-Me (Axon 1772)
References
Certificates
Categories
Extra info
T Honda et al. Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages. J. Med. Chem. 2000, 43(22), 4233-4246.
S Inoue et al. CDDO induces apoptosis via the intrinsic pathway in lymphoid cells. Leukemia 2004, 18(5), 948-952.
K Liby et al. The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling. Cancer Res. 2005, 65(11), 4789-4798.
SH Bernstein et al. The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood 2012, 119(14), 3321-3329.
Certificate of Analysis
Material Safety Data Sheet
Apoptosis
Cell Signaling & Oncology
Stem Cell Differentiator
PPAR
NR1C
A potent multifunctional anti-tumor agent. PPAR-γ agonist
Chemical name
(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic acid
Parent CAS No.
[218600-44-3]
Order
Size
Unit Price
Stock
10 mg
€110.00
In Stock | | axonmedchem |
| IMS 2186 | Axon 1827
CAS [1031206-36-6]
MF C18H16O4MW 296.32
Purity:
99%
Soluble in DMSO
Description
Apoptosis inducer blocking the cell cycle at G2 and inhibiting the production of PGE2/TNF-α; a long-acting anti-proliferative and anti-angiogenic agent; a small molecule developed as an anti-choroidal neovascularization (anti-CNV) drug
References
Certificates
Categories
Extra info
IA Falkenstein et al., Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr. Eye Res. 2008, 33, 599-609.
Certificate of Analysis
Material Safety Data Sheet
Angiogenesis
Apoptosis
Cell Cycle Regulation
Cell Signaling & Oncology
Immunology
Unclassified
Apoptosis inducer. Inhibitor of PGE2/TNF-α production
Chemical name
(E)-3-(3-hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one
Parent CAS No.
[1031206-36-6]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| R 55 - NSC 55712 | TPT 260 dihydrochloride | | Axon 2303
CAS [2076-91-7]
MF C8H14Cl2N4S3MW 333.32
Purity:
98%
Soluble in water and DMSO
Description
Retromer stabilizing pharmacological chaperone (Kd value ~5 μM) that binds at the Vps29 and Vps35 interface, and reduces Aβ peptide accumulation (IC50 value ~12 µM) and the pathogenic pathway of APP; useful pharmacological tool for research on Alzheimer's disease. Thiophene derivative R55 was originally tested and proved active for its anticancer activity against Yoshida sarcoma.
References
Certificates
Categories
Extra info
V.J. Mecozzi et al. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508.
V.N. Gogte et al. Synthesis of potential anticancer agents. I. Synthesis of substituted thiophenes. Tetrahedron. 1967 May;23(5):2437-41.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
CNS
Retromer
Retromer stabilizing pharmacological chaperone. Potential Alzheimer's therapeutic
Chemical name
thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
Parent CAS No.
[769856-81-7]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| CDDO-Me - Bardoxolone methyl | RTA 402 | Axon 1772
CAS [218600-53-4]
MF C32H43NO4MW 505.69
Purity:
98%
Soluble in DMSO
Description
Orally-available antioxidant inflammation modulator (AIM), being the most potent known inducer of the Nrf2 pathway; induces apoptosis of human tumor cells by disruption of redox balance and directly blocks IKKβ activity and thereby the NF-κB pathway
References
Certificates
Categories
Extra info
R Ahmad et al. Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179. J. Biol. Chem. 2006, 281, 35764-35769.
M Konopleva et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood 2002, 99(1), 326-335.
R Ahmad et al. Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation. Mol. Cancer Res. 2010, 8(7), 986-993.
MB Sporn et al. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J. Nat. Prod. 2011, 74(3), 537-545.
Certificate of Analysis
Material Safety Data Sheet
Apoptosis
Cell Signaling & Oncology
Immunology
Pain & Inflammation
Transcription Factors
NF-κB
EC 2.7.11.10
IKK
IKK-2 inhibitor; Inducer of the Nrf2 pathway
Chemical name
(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
Parent CAS No.
[218600-53-4]
Order
Size
Unit Price
Stock
5 mg
€85.00
In Stock | | axonmedchem |
| FLI 06 | Axon 2277
CAS [313967-18-9]
MF C25H30N2O5MW 438.52
Purity:
100%
Soluble in DMSO
Description
Notch signaling inhibitor (EC50 value 2.3 μM) that acts early in the secretory pathway. Although the precise molecular target of FLI 06 remains unclear, it effects a unique property to inhibit cargo recruitment to ER exit sites (ERESs) by changing its curvature. Consequently, it inhibits the membrane traffic of NotchΔE-eGFP at pre-ERES stages without fusion of ER-Golgi.FLI 06 does not inhibit the γ-secretase mediated proteolytical processing of NotchΔE-eGFP to NICD-eGFP at the plasma membrane.
References
Certificates
Categories
Extra info
A. Krämer et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat. Chem. Biol. 2013, 9, 731-738.
Certificate of Analysis
Material Safety Data Sheet
Angiogenesis
Cardiovascular
CNS
Epigenetics
Stem Cell
Endocrinology
Unclassified
ERES
Golgi
Notch signaling inhibitor that acts early in the secretory pathway
Chemical name
cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Parent CAS No.
[313967-18-9]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| Exo1 | Axon 2904
CAS [75541-83-2]
MF C15H12FNO3MW 273.26
Purity:
99%
Soluble in DMSO
Description
Exo1 is a chemical inhibitor of the exocytic pathway with an IC50 value of 20 µM. Exo1 induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus acutely inhibiting the traffic emanating from the endoplasmic reticulum. Moreover, Exo1 induces the rapid release of ADP-ribosylation factor (ARF) 1 from Golgi membranes but has less effect on the organization of the trans-Golgi network.
KEYWORDS: Exo1 | supplier | Exocytic pathway inhibitor | Exo 1 | Exo-1 | CAS [75541-83-2] | Golgi apparatus | Inhibitor | Proteins | ADP-ribosylation factor 1 | ARF 1 | Endoplasmic reticulum | | axonmedchem |
| Deltarasin trihydrochloride | Axon 2284
CAS [1440898-82-7]
MF C40H37N5O.3HClMW 713.14
Purity:
99%
Optical purity:
Optically pure
Soluble in water and DMSO
Description
Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS.
References
Certificates
Categories
Extra info
G. Zimmermann et al.Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling. Nature 2013, 497, 638-642.
B. Frett et al. Targeting the K-Ras/PDEδ Protein–Protein Interaction: The Solution for Ras-Driven Cancers or Just Another Therapeutic Mirage? ChemMedChem 2013, 8, 1620-1622.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
MAPK
PDE
Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction.
Chemical name
(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethylphenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole trihydrochloride
Parent CAS No.
[1440898-61-2]
Order
Size
Unit Price
Stock
5 mg
€115.00
In Stock | | axonmedchem |
| Etiracetam - UCB 6474 | Axon 1109
CAS [33996-58-6]
MF C8H14N2O2MW 170.21
Purity:
98%
No solubility data
Description
Acetylcholine agonist; a nootropic drug of the racetam family; Its more active S-enantiomer is Levetiracetam (Axon 1110). in comparison with the opposite R-enantiomer, UCB L-060 (Axon 1111)
References
Certificates
Categories
Extra info
Hovinga CA: Levetiracetam: a novel antiepileptic drug. Pharmacotherapy 2001, 21(11), 1375-1388.
CNS
SV2A
Unclassified
Racemate of Axon 1110 and Axon 1111
Chemical name
2-(2-Oxo-pyrrolidin-1-yl)-butyramide
Parent CAS No.
[33996-58-6]
Order
Size
Unit Price
Stock
10 mg
€75.00
In Stock | | axonmedchem |
| ARN 272 | Axon 2941
CAS [488793-85-7]
MF C27H20N4O2MW 432.47
Purity:
98%
Soluble in DMSO
Recently added | | axonmedchem |
| Levetiracetam - UCB-L 059 | Keppra | Axon 1110
CAS [102767-28-2]
MF C8H14N2O2MW 170.21
Purity:
99%
Optical purity:
99% ee
Soluble in water and DMSO
Description
Acetylcholine agonist; "Second generation" nootropic; an anticonvulsant medication used to treat epilepsy; more active enantiomer of Etiracetam (Axon 1109), in comparison with the opposite (R)-enantiomer, UCB L-060 (Axon 1111)
References
Certificates
Categories
Extra info
Hovinga CA: Levetiracetam: a novel antiepileptic drug. Pharmacotherapy 2001, 21(11), 1375-1388.
Certificate of Analysis
Material Safety Data Sheet
CNS
SV2A
Unclassified
Binds synaptic vesicle protein 2A (SV2A)
Chemical name
(S)-2-(2-Oxo-pyrrolidin-1-yl)-butyramide
Parent CAS No.
[102767-28-2]
Order
Size
Unit Price
Stock
20 mg
€85.00
In Stock | | axonmedchem |
| NEO 212 - TMZ-POH | Axon 2327
CAS [1361198-79-9]
MF C17H20N6O4MW 372.38
Purity:
99%
Optical purity:
Optically pure
Soluble in DMSO
Description
Novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo (IC50 values 5-50 µM for cytotoxicity on glioma cell lines). NEO 212 causes DNA damage and cell death much more efficiently than TMZ, because linkage with POH increased its biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions.NEO212 is a conjugate of temozolomide (TMZ, Axon 2326) with the natural product perillyl alcohol (POH) and circumvents TMZ-resistance in multiple cancer cell lines and gliomas.
References
Certificates
Categories
Extra info
T.C. Chen et al. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol. Cancer Ther. 2014, 13, 1181-1193.
H.Y. Cho et al. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol. Cancer Ther. 2014, 13, 2004-2017.
Certificate of Analysis
Material Safety Data Sheet
Apoptosis
Cell Cycle Regulation
Cell Signaling & Oncology
DNA-damage Response
DNA
DNA alkylating agent; chemotherapeutic
Chemical name
(S)-(4-(Prop-1-en-2-yl)cyclohex-1-enyl)methyl 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonylcarbamate
Parent CAS No.
[1361198-79-9]
Order
Size
Unit Price
Stock
5 mg
€110.00
In Stock | | axonmedchem |
| Reboxetine mesylate | Axon 1240
CAS [98769-84-7]
MF C19H23NO2.CH4SO3MW 409.50
Purity:
99%
Soluble in DMSO
Description
Selective noradrenaline uptake inhibitor (NARI); orally active.
KEYWORDS: Reboxetine mesylate | supplier | NARI | CAS [98769-84-7] | [71620-89-8] | Adrenaline | (Nor-) | NARI | Inhibitor | Proteins | | axonmedchem |
| Remogliflozin - GSK 189074 | Axon 1634
CAS [329045-45-6]
MF C23H34N2O7MW 450.53
Purity:
99%
Soluble in water and DMSO
Description
Remogliflozin inhibits the sodium-glucose transport (SGLT2) proteins, which are responsible for glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Its prodrug is Remoglifozin etabonate (GSK 189075), investigated as a treatment of anti diabetes type II
References
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Extra info
Y Fujimori et al. Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. J. Pharmacol. Exp. Ther. 2008, 327(1), 268-276.
Certificate of Analysis
Material Safety Data Sheet
Diabetes & Metabolism
SGLT2
Sodium-Glucose Co-transproter
SGLT2 inhibitor
Chemical name
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1H-pyrazol-3-yloxy)tetrahydro-2H-pyran-3,4,5-triol
Parent CAS No.
[329045-45-6]
Order
Size
Unit Price
Stock
5 mg
€135.00
In Stock | | axonmedchem |
| Sertraline hydrochloride | Axon 1300
CAS [79559-97-0]
MF C17H17Cl2N.HClMW 342.69
Purity:
99%
Soluble in DMSO
Description
Selective serotonin reuptake inhibitor (SSRI); antidepressant
References
Certificates
Categories
Extra info
Koe et al. Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J. Pharmacol. Exp. Ther. 1983, 226,686.
Certificate of Analysis
Material Safety Data Sheet
CNS
SSRI
Unclassified
SSRI; Antidepressant
Chemical name
[(1S,4S)-4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine hydrochloride
Parent CAS No.
[79617-96-2]
Order
Size
Unit Price
Stock
10 mg
€85.00
In Stock | | axonmedchem |
| STF 31 | Axon 1905
CAS [724741-75-7]
MF C23H25N3O3SMW 423.53
Purity:
99%
Soluble in DMSO
Description
Inhibitor of glucose transporter 1 (GLUT1)
References
Certificates
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Extra info
DA Chan et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci. Transl. Med. 2011, 3(94), 94ra70.
Certificate of Analysis
Material Safety Data Sheet
Cell Signaling & Oncology
Diabetes & Metabolism
GLUT1
Unclassified
Inhibitor of glucose transporter 1 (GLUT1)
Chemical name
4-((4-tert-butylphenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide
Parent CAS No.
[724741-75-7]
Order
Size
Unit Price
Stock
10 mg
€125.00
In Stock | | axonmedchem |
| SSR 504734 | Axon 1549
CAS [615571-23-8]
MF C20H20ClF3N2O.HClMW 433.29
Purity:
99%
Optical purity:
optical pure
Soluble in water and DMSO
Description
A potent, selective and orally active GlyT-1 inhibitor, blocked the ex vivo uptake of glycine rapidly, reversibly, and for a long duration; exhibiting activity in animal models of schizophrenia, anxiety and depression
References
Certificates
Categories
Extra info
G Depoortere et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology 2005, 30, 1963–1985.
K Hashimoto. Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia. Recent Pat. CNS Drug Discov. 2006, 1, 43-53.
Certificate of Analysis
Material Safety Data Sheet
CNS
GlyT-1
Unclassified
GlyT-1 inhibitor
Chemical name
2-chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride
Parent CAS No.
[742693-38-5]
Order
Size
Unit Price
Stock
2 mg
€105.00
In Stock | | axonmedchem |
| Fenfluramine hydrochloride | Axon 2850
CAS [404-82-0]
MF C12H16F3N.HClMW 267.72
Purity:
99%
Soluble in water and DMSO
Description
5-HT releasing agent.
KEYWORDS: Fenfluramine hydrochloride | supplier | 5-HT releasing agent | CAS [404-82-0] | [458-24-2] | Serotonin | 5-HT | Releasing agent | Unclassified | | axonmedchem |
| BAY-876 | Axon 2660
CAS [1799753-63-1]
MF C24H16F4N6O2MW 496.42
Purity:
99%
Soluble in DMSO
Description
BAY-876 is a higly selective GLUT1 inhibitor (IC50 value 2 nM). In vitro PK data showed that BAY-876 was very stable in liver microsomes and hepatocytes; preliminary in vivo PK studies demonstrated a good oral bioavailability and long terminal half-life.
KEYWORDS: BAY-876 | supplier | GLUT1 inhibitor | BAY876 | BAY 876 | CAS [1799753-63-1] | Glucose | GLUT1 | Inhibitor | Proteins | Transporter | Glucose Transporter 1 | | axonmedchem |
| ORG 25935 - SCH 900435 | Axon 1563
CAS [949588-40-3]
MF C21H25NO3.HClMW 375.89
Purity:
99%
Soluble in DMSO
Description
Potent and selective GlyT-1 glycine transporter or reuptake inhibitor; a therapeutic intended for the treatment of neurological disorders
References
Certificates
Categories
Extra info
HH Lidoe et al. The glycine reuptake inhibitor Org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens. Alcoholism: Clin. Exp. Res. 2009, 33(7), 1151-1157.
K Morita et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J. Pharmacol. Exp. Ther. 2008, 326(2), 633-645.
A Molander et al. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male Wistar rats. Alcohol and Alcoholism (Oxford, United Kingdom) (2007), 42(1), 11-18.
K Hashimoto. Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia. Recent Patents on CNS Drug Discovery, 2006, 1, 43-53.
Certificate of Analysis
Material Safety Data Sheet
CNS
GlyT-1
Unclassified
GlyT-1 inhibitor
Chemical name
[((1R,2S)-6-Methoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-methyl-amino]-acetic acid hydrochloride, rel-
Parent CAS No.
[1147011-84-4]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| ALX 5407 hydrochloride - NFPS | Axon 1238
CAS [200006-08-2]
MF C24H24FNO3.HClMW 429.91
Purity:
99%
Optical purity:
98% ee
Soluble in DMSO
Description
Potent, selective, irreversible hGlyT-1 glycine transporter inhibitor.
KEYWORDS: ALX 5407 HCl | supplier | GlyT-1 inhibitor | NFPS | ALX5407 | NFPS | CAS [200006-08-2] | [571147-18-7] | Glycine | transporter | GlyT1 | schizophrenia | CNS | neurotransmitter | | axonmedchem |
| LY 393558 | Axon 1139
CAS [271780-64-4]
MF C26H31FN4O4S2MW 546.68
Purity:
99%
Moderately soluble in DMSO and Ethanol
Description
Serotonin reuptake inhibitor and 5-HT1B/1D antagonist.
KEYWORDS: LY 393558 | SSRI | supplier | 5-HT1B/1D antagonist | LY393558 | CAS [271780-64-4] | Serotonin | 5-HT1B | 5-HT1D | 5-HT (Non Selective) | Antagonist | Receptors | | axonmedchem |
| Azaphen - Azafen | Azaphenonxazine dihydrochloride | Axon 1462
CAS [24853-80-3]
MF C16H19N5O.2HClMW 370.28
Purity:
99%
Soluble in water
Description
An antidepressant having effects on the autonomic nervous system; the drug is especially effective for mild and moderate depressions and a combination of Azaphen and Thymol is applicable for severa depressions. Azaphen improves sleep too
References
Certificates
Categories
Extra info
NN Shinaev, AG Akzhigitov. Azaphen: a return to clinical practice. (Article in Russian). Zh Nevrol Psikhiatr Im S S Korsakova. 2005, 105(10), 55-6.
Certificate of Analysis
Material Safety Data Sheet
CNS
SSRI
Unclassified
Antidepressant
Chemical name
10-Methyl-3-(4-methyl-piperazin-1-yl)-10H-9-oxa-1,2,10-triaza-anthracene dihydrochloride
Parent CAS No.
[24886-52-0]
Order
Size
Unit Price
Stock
10 mg
€105.00
In Stock | | axonmedchem |
| Fluvoxamine maleate | Axon 1556
CAS [61718-82-9]
MF C15H21F3N2O2.C4H4O4MW 434.41
Purity:
99%
Soluble in DMSO
Description
Selective serotonin reuptake inhibitor (SSRI), with Ki value to be 1.6 nM
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
SSRI
Unclassified
SSRI
Chemical name
5-Methoxy-1-(4-trifluoromethyl-phenyl)-pentan-1-one O-(2-amino-ethyl)-oxime maleate
Parent CAS No.
[54739-18-3]
Order
Size
Unit Price
Stock
10 mg
€65.00
In Stock | | axonmedchem |
| Paroxetine hydrochloride | Axon 1452
CAS [110429-35-1]
MF C19H20FNO3.HClMW 365.83
Purity:
99%
Optical purity:
>98% ee
Soluble in water and DMSO
Description
Selective serotonin reuptake inhibitor (SSRI); Paroxetine is used to treat major depression, obsessive-compulsive, panic, social anxiety, and generalised anxiety disorders in adult outpatients.Paroxetine has also been identified an inhibitor of GRK2 activity both in vitro and in living cells with up to 60-fold selectivity over other GRKs, and is capable of increasing myocardial contractility.
References
Certificates
Categories
Extra info
S.R. Grimsley et al. Paroxetine, sertraline, and fluvoxamine: new selective serotonin reuptake inhibitors. Clin Pharm. 1992 Nov;11(11):930-57.
D.M. Thal et al. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol. 2012 Nov 16;7(11):1830-9.
L. Weber et al. Paroxetine: a first for selective serotonin reuptake inhibitors - a new use: approved for vasomotor symptoms in postmenopausal women. Womens Health (Lond Engl). 2014 Mar;10(2):147-54.
Certificate of Analysis
Material Safety Data Sheet
CNS
SSRI
Unclassified
GRK
SSRI
Chemical name
(S)-3-(Benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluoro-phenyl)-piperidine hydrochloride
Parent CAS No.
[61869-08-7]
Order
Size
Unit Price
Stock
10 mg
€75.00
In Stock | | axonmedchem |
| Fluoxetine hydrochloride | Axon 1302
CAS [56296-78-7]
MF C17H18F3NO.HClMW 345.79
Purity:
99%
Soluble in DMSO
Description
Selective serotonin reuptake inhibitor (SSRI)
References
Certificates
Categories
Extra info
Wong et al., Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci. 1995, 57, 411-441.
Gobert et al. Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin (5-HT) in the frontal cortex of freely moving rats by combined blockade of 5-HT1A/1B receptors with WAY 100365 and GR 127935. J. Neurochem. 1997, 68, 1159-1163.
Certificate of Analysis
Material Safety Data Sheet
CNS
SSRI
Unclassified
SSRI
Chemical name
Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine hydrochloride
Parent CAS No.
[54910-89-3]
Order
Size
Unit Price
Stock
10 mg
€75.00
In Stock | | axonmedchem |
| Citalopram hydrobromide - ZD 211 | LU 10-171 | Axon 1320
CAS [59729-32-7]
MF C20H21FN2O.HBrMW 405.30
Purity:
98%
Soluble in DMSO
Description
A very selective serotonin reuptake inhibitor (SSRI); Citalopram is used as an antidepressant drug on the market
References
Certificates
Categories
Extra info
P Baumann et al. A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients. J. Clin. Psychopharmacol. 1996, 16, 307-314.
RKR Salokangas et al. Citalopram as an adjuvant in chronic schizophrenia: a double-blind placebo-controlled study. Acta Psychiatr Scand 1996, 94, 175-180.
CA Naranjo et al. Using fuzzy logic to predict response to citalopram in alcohol dependence. Clin. Pharmacol. Ther. 1997, 62, 209-224.
Certificate of Analysis
Material Safety Data Sheet
CNS
SSRI
Unclassified
SSRI; Antidepressant
Chemical name
1-(3-Dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile hydrobromide
Parent CAS No.
[59729-33-8]
Order
Size
Unit Price
Stock
10 mg
€75.00
In Stock | | axonmedchem |
| BTS 54-505 | Axon 1257
CAS [84484-78-6]
MF C15H22ClN.HClMW 288.26
Purity:
98%
No solubility data
Description
5-HT uptake inhibitor; A major pharmacologically active metabolite of the anti-obesity drug, sibutramine
References
Certificates
Categories
Extra info
DJ Heal et al. A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agents. Br. J. Pharmacol. 1998, 125, 301–308.
Certificate of Analysis
Material Safety Data Sheet
CNS
Diabetes & Metabolism
SSRI
Unclassified
5-HT uptake inhibitor
Chemical name
1-[1-(4-Chloro-phenyl)-cyclobutyl]-3-methyl-butylamine hydrochloride
Parent CAS No.
[84467-54-9]
Order
Size
Unit Price
Stock
10 mg
€85.00
In Stock | | axonmedchem |
| Venlafaxine hydrochloride - Venlift | Vexor | WY 45030 | Axon 1727
CAS [99300-78-4 ]
MF C17H27NO2.HClMW 313.86
Purity:
99%
Soluble in water and DMSO
Description
Serotonin-norepinephrine reuptake inhibitor (SNRI); an antidepressant for the treatment of major depressive disorder (MDD) etc
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Unclassified
SNRI
Chemical name
1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride
Parent CAS No.
[93413-69-5]
Order
Size
Unit Price
Stock
10 mg
€65.00
In Stock | | axonmedchem |
| WY 45494 hydrochloride - Venlafaxine Impurity D | Axon 1724
CAS [93413-90-2]
MF C16H25NO2.HClMW 299.84
Purity:
99%
Soluble in DMSO
Description
Metabolite of Venlafaxine (Axon 1727), a serotonin-norepinephrine reuptake inhibitor (SNRI)
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Unclassified
Metabolite of Venlafaxine; SNRI
Chemical name
1-(1-(4-methoxyphenyl)-2-(methylamino)ethyl)cyclohexanol hydrochloride
Parent CAS No.
[149289-30-5]
Order
Size
Unit Price
Stock
5 mg
€75.00
In Stock | | axonmedchem |
| WY 45960 hydrochloride - Venlafaxine Impurity F | Axon 1723
CAS [93413-79-7 ]
MF C17H25NO.HClMW 295.85
Purity:
100%
Soluble in DMSO
Description
Metabolite of Venlafaxine (Axon 1727), a serotonin-norepinephrine reuptake inhibitor (SNRI)
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Unclassified
Metabolite of Venlafaxine; SNRI
Chemical name
2-cyclohexenyl-2-(4-methoxyphenyl)-N,N-dimethylethanamine hydrochloride
Parent CAS No.
[93413-57-1]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| WY 46689 - Didesmethyl Venlafaxine, N,O- | Axon 1725
CAS [135308-74-6]
MF C15H23NO2MW 249.35
Purity:
100%
Soluble in DMSO
Description
Metabolite of Venlafaxine (Axon 1727), a serotonin-norepinephrine reuptake inhibitor (SNRI)
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Unclassified
Metabolite of Venlafaxine; SNRI
Chemical name
4-(1-(1-hydroxycyclohexyl)-2-(methylamino)ethyl)phenol
Parent CAS No.
[135308-74-6]
Order
Size
Unit Price
Stock
5 mg
€75.00
In Stock | | axonmedchem |
| Desmethylvenlafaxine succinate, O- - DVS 233 succinate | Axon 2116
CAS [448904-47-0]
MF C16H25NO2.C4H6O4MW 381.46
Purity:
100%
Soluble in water and DMSO
Description
Active metabolite of Venlafaxine (Axon 1727), a serotonin-norepinephrine reuptake inhibitor (SNRI). Racemate of Axon 1720 and 1721.
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Pfizer Licensed Products
Metabolite of Venlafaxine; SNRI
Chemical name
4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate
Source information
Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.
Parent CAS No.
[93413-62-8]
Order
Size
Unit Price
Stock
10 mg
€90.00
In Stock | | axonmedchem |
| Amoxapine | Axon 1333
CAS [14028-44-5]
MF C17H16ClN3OMW 313.78
Purity:
99%
Soluble in DMSO
Description
Tricyclic antidepressant; a strong reuptake inhibitor of norepinephrine and weak reuptake inhibitor of serotonin. One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect.
References
Certificates
Categories
Extra info
S. Kapur et al. Is amoxapine an atypical antipsychotic? Positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy. Biol. Psychiatry. 1999, 45, 1217-1220.
J.L. Kinney et al. Evaluation of amoxapine. Clin. Pharm. 1982, 1, 417-424.
Certificate of Analysis
Material Safety Data Sheet
CNS
NRI
Tricyclic antidepressant; Potent reuptake inhibitor of norepinephrine (NRI)
Chemical name
2-Chloro-11-piperazin-1-yl-dibenzo[b,f][1,4]oxazepine
Parent CAS No.
[14028-44-5]
Order
Size
Unit Price
Stock
50 mg
€50.00
In Stock | | axonmedchem |
| Dinorvenlafaxine - Didesmethyl Venlafaxine, N,N- | Venlafaxine EP Impurity C | Axon 1726
CAS [93413-77-5]
MF C15H23NO2MW 249.35
Purity:
100%
Soluble in DMSO
Description
Metabolite of Venlafaxine (Axon 1727), a serotonin-norepinephrine reuptake inhibitor (SNRI)
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Unclassified
Metabolite of Venlafaxine; SNRI
Chemical name
1-(2-amino-1-(4-methoxyphenyl)ethyl)cyclohexanol
Parent CAS No.
[93413-77-5]
Order
Size
Unit Price
Stock
5 mg
€75.00
In Stock | | axonmedchem |
| Deshydroxy Venlafaxine HCl - Venlafaxine Impurity G | Axon 1722
CAS [1076199-92-2 (parent)]
MF C17H27NO.HClMW 297.86
Purity:
98%
Soluble in DMSO
Description
Metabolite of Venlafaxine (Axon 1727), a serotonin-norepinephrine reuptake inhibitor (SNRI)
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Unclassified
Metabolite of Venlafaxine; SNRI
Chemical name
2-cyclohexyl-2-(4-methoxyphenyl)-N,N-dimethylethanamine hydrochloride
Parent CAS No.
[1076199-92-2]
Order
Size
Unit Price
Stock
5 mg
€95.00
In Stock | | axonmedchem |
| Desmethylvenlafaxine, S-(+)-O- - Desvenlafaxine, S-(+)-O- | Axon 1721
CAS [142761-12-4]
MF C16H25NO2MW 263.38
Purity:
100%
Optical purity:
Optically pure
Soluble in DMSO
Description
Active metabolite of Venlafaxine (Axon 1727), a serotonin-norepinephrine reuptake inhibitor (SNRI)
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Unclassified
Metabolite of Venlafaxine; SNRI
Chemical name
(S)-4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol
Parent CAS No.
[142761-12-4]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| Desmethylvenlafaxine, R-(-)-O- - Desvenlafaxine, R-(-)-O- | Axon 1720
CAS [142761-11-3]
MF C16H25NO2MW 263.38
Purity:
98%
Optical purity:
Optically pure
Soluble in DMSO
Description
Active metabolite of Venlafaxine (Axon 1727), a serotonin-norepinephrine reuptake inhibitor (SNRI)
References
Certificates
Categories
Extra info
EA Muth et al. Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem. Pharmacol. 1986, 35(24), 4493–4497.
FP Bymaster et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001, 25(6), 871–80.
Certificate of Analysis
Material Safety Data Sheet
CNS
SNRI
Unclassified
Metabolite of Venlafaxine; SNRI
Chemical name
(R)-4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol
Parent CAS No.
[142761-11-3]
Order
Size
Unit Price
Stock
5 mg
€125.00
In Stock | | axonmedchem |
| Atomoxetine hydrochloride | Axon 1297
CAS [82248-59-7]
MF C17H21NO.HClMW 291.82
Purity:
99%
Optical purity:
>98% ee
Soluble in water
Description
Norepinephrine reuptake inhibitor (NRI), or noradrenaline reuptake inhibitor (NARI)
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
CNS
NRI
Unclassified
NRI inhibitor
Chemical name
Methyl-((R)-3-phenyl-3-o-tolyloxy-propyl)-amine hydrochloride
Parent CAS No.
[83015-26-3]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | axonmedchem |
| Radafaxine hydrochloride - BW 306U | GW 353162A | Axon 1123
CAS [106083-71-0]
MF C13H18ClNO2.HClMW 292.20
Purity:
99%
Optical purity:
Optically pure
Soluble in water
Description
A norepinephrine-dopamine reuptake inhibitor (NDRI); a potent metabolite of bupropion; radafaxine is a (+)-isomer of hydroxybupropion
KEYWORDS: Radafaxine HCl | supplier | NDRI | BW 306U | GW 353162A | BW306U | GW353162A | CAS [106083-71-0] | [192374-14-4] | Noradrenaline | Dopamine | NDRI | reuptake | antidepressant | bupropion | hydroxybupropion | metabolite | Inhibitor | norepinephrine | | axonmedchem |