Athens Research & Technology;16-14-021609;Bacterial/Permeability-Increasing Protein, Human Neutrophil (BPI, CAP57)

品牌:athens research & technology

Athens Research & Technology 公司位于美国乔治亚州雅典市,从1986年以来一直致力于纯化高纯度,高活性的人类蛋白质和开发这些蛋白的多克隆抗血清。我们的常规产品包括丝氨酸蛋白酶、蛋白酶抑制剂、中性粒细胞酶、载脂蛋白、脂蛋白,血小板蛋白、转铁蛋白、免疫球蛋白等。二十年多年来,世界各地的研究人员都在使用我们公司的产品。在炎症、冠状动脉疾病、自身免疫性疾病、癌症、老年痴呆症等等研究的主要科学出版物中都能看到引用我们公司的产品。
我们提供优质,可靠的产品和出色的客户服务。我们期待着您的业务。如果需要定制研究服务,Athens Research & Technology 公司能够根据您的项目要求提供无与伦比的试剂。

MW: 55,000
Extinction Coefficient: 1.0

Frozen in 80 mM Citrate Phosphate, pH 5.6, 0.75 M NaCl.

Storage: -70°C or lower

Buy Purified Native Bacterial/Permeability-Increasing Protein (BPI,CAP57), Human Neutrophil. 
Bulk Qty Available.

Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.

Purity: >=95% by SDS-PAGE

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citation:

Zhao M.H., Jones S.J., and Lockwood C.M.. Clin Exp Immunol 1995. 99, 49. Elsbach P., and Weiss J. Immunobiology 1993. 187, 417.

Budding, K., E. A. van de Graaf, T. Hoefnagel, C. E. Hack, and H. G. Otten. "Anti-BPIFA1/SPLUNC1: A new autoantibody prevalent in patients with endstage cystic fibrosis." Journal of Cystic Fibrosis (2013).

Baron, Olga Lucia, Pieter van West, Benoit Industri, Michel Ponchet, Géraldine Dubreuil, Benjamin Gourbal, Jean-Marc Reichhart, and Christine Coustau. "Parental Transfer of the Antimicrobial Protein LBP/BPI Protects Biomphalaria glabrata Eggs against Oomycete Infections." PLoS Pathogens 9, no. 12 (2013): e1003792.

Skopelja S, Hamilton BJ, Jones JD, Yang ML, Mamula M, Ashare A, Gifford AH, Rigby WF.
The role for neutrophil extracellular traps in cystic fibrosis autoimmunity.
JCI Insight. 2016 Oct 20;1(17):e88912.