Athens Research & Technology;16-20-201319;Thrombospondin, Human Platelet

型号:16-20-201319
联系人:程园
联系电话:18611717737
品牌:athens research & technology


Athens Research & Technology 公司位于美国乔治亚州雅典市,从1986年以来一直致力于纯化高纯度,高活性的人类蛋白质和开发这些蛋白的多克隆抗血清。我们的常规产品包括丝氨酸蛋白酶、蛋白酶抑制剂、中性粒细胞酶、载脂蛋白、脂蛋白,血小板蛋白、转铁蛋白、免疫球蛋白等。二十年多年来,世界各地的研究人员都在使用我们公司的产品。在炎症、冠状动脉疾病、自身免疫性疾病、癌症、老年痴呆症等等研究的主要科学出版物中都能看到引用我们公司的产品。
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Special Note: This product is aliquoted in siliconized tubes and must be handled using siliconized containers and pipette tips.

MW: 420,000
Extinction Coefficient: 0.91

Lyophilized from 20 mM Tris-HCl, pH 8.0, with 600 mM NaCl, 2 mM CaCl2, and 20% sucrose
Reconstitution: After initial centrifugation, we suggest the addition of de-ionized H2O to the original volume, followed by gentle swirling and/or vortexing to ensure adequate homogenization. This product may precipitate at concentrations greater than 0.50 mg/ml.


A cellular adhesion protein. Thrombospondin is a component of the coagulation mechanism and is believed to have potential as a marker for platelet activation and renal failure.


Storage: -20°C

Purity: >=95% by SDS-PAGE

Prepared from platelets shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Synonym: THBS1, THBS, TSP1, TSP, Thrombospondin-1


Product Citations:
Stein, Jeffrey J., Chinenye Iwuchukwu, Kristopher G. Maier, and Vivian Gahtan. "Thrombospondin-1-induced smooth muscle cell chemotaxis and proliferation are dependent on transforming growth factor-β2 and hyaluronic acid synthase. Molecular and cellular biochemistry(2013): 1-6.

Haredy, Ahmad M., Akitoshi Nishizawa, Kohsuke Honda, Tomoshi Ohya, Hisao Ohtake, and Takeshi Omasa. "Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression. Cytotechnology(2013): 1-10.

Green, David E., Bum-Yong Kang, Tamara C. Murphy, and C. Micheal Hart. "Peroxisome proliferator-activated receptor gamma (PPARγ) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation. Pulmonary circulation 2, no. 4 (2012): 483

Métayer LE, Vilalta A, Burke GAA, Brown GC. 
Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis. 
Oncotarget, Advance Publications 2017.

Neubauer EF, et al. A diverse host thrombospondin-type-1 repeat protein repertoire promotes symbiont colonization during establishment of cnidarian-dinoflagellate symbiosis. Elife. 2017 May 8;6. pii: e24494. doi: 10.7554/eLife.24494.

Arias DL, et al. HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction. Cardiovasc Res. 2016 Jan 1;109(1):115-30. doi: 10.1093/cvr/cvv243. Epub 2015 Oct 26.

Nevitt C, McKenzie G, Christian K, Austin J, Hencke S, Hoying J, LeBlanc A. Physiological levels of thrombospondin-1 decrease NO-dependent vasodilation in coronary microvessels from aged rats.
Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1842-50. doi: 10.1152/ajpheart.00086.2016. Epub 2016 May 3.

Murmann T, et al. Staurosporine and Extracellular Matrix Proteins Mediate the Conversion of Small Cell Lung Carcinoma Cells into a Neuron-Like Phenotype. PLoS One. 2014 Feb 28;9(2):e86910. doi: 10.1371/journal.pone.0086910. eCollection 2014.