Athens Research & Technology;16-12-030112;Cathepsin L, Human Liver

型号:16-12-030112
联系人:程园
联系电话:18611717737
品牌:athens research & technology


Athens Research & Technology 公司位于美国乔治亚州雅典市,从1986年以来一直致力于纯化高纯度,高活性的人类蛋白质和开发这些蛋白的多克隆抗血清。我们的常规产品包括丝氨酸蛋白酶、蛋白酶抑制剂、中性粒细胞酶、载脂蛋白、脂蛋白,血小板蛋白、转铁蛋白、免疫球蛋白等。二十年多年来,世界各地的研究人员都在使用我们公司的产品。在炎症、冠状动脉疾病、自身免疫性疾病、癌症、老年痴呆症等等研究的主要科学出版物中都能看到引用我们公司的产品。
我们提供优质,可靠的产品和出色的客户服务。我们期待着您的业务。如果需要定制研究服务,Athens Research & Technology 公司能够根据您的项目要求提供无与伦比的试剂。
产品特色
多种天然提取的人类蛋白质产品;多种兔抗人类蛋白质抗血清。




MW: 25,000 - 29,000
Extinction Coefficient: 1.28

Frozen in 20 mM Malonate, pH 5.5, 1 mM EDTA, 400 mM NaCl.

Storage: -70°C or lower

Buy Purified Native Human Cathepsin L (CatL), Human Liver. 
Bulk Qty Available.

The most powerful of the lysosomal proteases. It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates. The level of cathepsin L is a strong predictor of relapse and survival following treatment of a primary breast tumor.

Activity: Greater than 1 unit per mg of protein. One unit is defined as the amount of enzyme that hydrolyzes one micromole of Z-Phe-Arg-AFC per minute at 25oC using 400 mM Na Acetate, pH 5.5 with 4 mM EDTA and 8 mM DTT as the activation buffer in the presence of Brij.

Prepared from tissue shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citation:
Armstrong, Andrea, Niklas Mattsson, Hanna Appelqvist, Camilla Janefjord, Linnea Sandin, Lotta Agholme, Bob Olsson et al. "Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer’s Disease." Neuromolecular medicine (2013): 1-11
Miller, Bailey, Aaron J. Friedman, Hyukjae Choi, James Hogan, J. Andrew McCammon, Vivian Hook, and William H. Gerwick. "The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L." Journal of natural products (2013).


References:
Mason, R.W., Green, G.D.J. and Barrett, A.J. 1985. Biochem. J. 226, 233.
Klijn et al. 1998. J. Clin. Onc.16, 1013.
Barrett, A.J. and Kirschke, H. 1981. Methods Enzoymol. 80, 535.
Tchope, J.R. et al. 1991. Biochem. Biophys. Acta. 1076. 149.