聚焦超声血脑屏障系统(Focused Ultrasound System)



Bench-top focused ultrasound



The focused ultrasound system that enables targeted brain exposures without the need for concurrent imaging.
The RK-50 is a stand-alone, versatile, preclinical system designed to take advantage of the various applications of focused ultrasound. Through the use of traditional stereotaxic targeting methods, the RK-50 can deliver precise doses of FUS through an intact skull to small structures in the rodent brain. The system can also be used to automatically raster a series of FUS exposures to cover an arbitrary volume. Applications include ablation, blood-brain barrier disruption, and neuromodulation.
  • Precise, fast targeting with 3-axis positioning system
  • Treatment planning software facilitates stereotaxic-guided target selection and exposure control (runs on included PC)
  • Multi-point targeting is achievable in line, raster, and circular exposures
  • Focused ultrasound dose settings can be easily controlled for any application
  • Utilizes calibrated focused ultrasound transducers, available in a range of frequencies

  • 二、RK-100影像导航的聚焦超声系统

     MRI-compatible image-guided focused ultrasound system


    The MRI-compatible image-guided focused ultrasound system consists of a computer-controlled high-precision three-axis positioning system and a high-power focused ultrasound transducer coupled.
    The positioning system enables delivery of focused ultrasound energy to precise locations in soft tissue. The system is designed specifically for research in small to large animal models to investigate ultrasound-tissue interactions, and to evaluate the safety of therapeutic approaches prior to translation into humans. The entire FUS system fits within the bore of a clinical MR or CT scanner for image-guided treatment planning and delivery. The system is completely non-magnetic, enabling it to function within a high-field magnetic resonance imager for image-guided treatment planning and monitoring of ultrasound exposures. In addition, the system is compatible with X-ray CT imaging as well.
    Inside every RK-100 is a custom-built and calibrated focused ultrasound transducer capable of exposing millimeter – size volumes of tissue within a subject.
    The non-magnetic positioning system can translate the transducer along arbitrary 3D paths during imaging. The delivery of ultrasound exposures is achieved using images acquired with MRI or CT, depending on the configuration of the system. Real-time monitoring of forward and reflected electrical power to the transducer enables consistent delivery of energy during experiments.
    The system is capable of delivering exposures ranging from high-power continuous sonications for thermal coagulation of soft tissues, to pulsed sonications suitable for applications such as tissue lysis, drug delivery, or vascular permeabilization. Since the system is designed for research it is designed to be flexible, offering users the capability to design their experiments to suit their needs.



    The RK-300 is a focused ultrasound system created to be used within small-bore preclinical imaging systems.
    This platform is specifically designed for the exposure of small animal models and is particularly suited for blood brain barrier disruption studies.  It includes image-guided targeting software, an integrated computer controlled high precision two-axis positioning system, and a calibrated focused ultrasound transducer.  The RK-300 is the only system in the world capable of performing non-invasive hyperthermia, ablation and blood brain barrier opening within a small bore preclinical imaging system.
  • Calibrated focused ultrasound transducer offered in a range of frequencies from 750kHz to 5MHz fundamental frequency (custom focal lengths are available)
  • 2-axis spatial positioning (20mm travel, 0.25mm precision)
  • Capable of pulsed and continuous ultrasound exposures
  • Image-based treatment planning software
  • Integrated RF surface coil
  • Compatible with bore sizes down to 70mm
  • 文献案例

    Studies using FUS Instruments’ Systems




    Thévenot, Emmanuel, et al. “Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound.” Human gene therapy 23.11 (2012): 1144-1155.


    Staruch, Robert, Rajiv Chopra, and Kullervo Hynynen. “Hyperthermia in Bone Generated with MR Imaging–controlled Focused Ultrasound: Control Strategies and Drug Delivery.” Radiology 263.1 (2012): 117-127.


    Burgess, Alison, et al. “Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier.” PLoS One 6.11 (2011): e27877.


    Jord?o, Jessica F., et al. “Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-β plaque load in the TgCRND8 mouse model of Alzheimer’s disease.” PloS one 5.5 (2010): e10549.


    Blood-Brain Barrier Disruption Studies


    Wang, S., et al. “Noninvasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virus.” Gene Therapy 22.1 (2015): 104-110.


    McDannold, Nathan, et al. “Temporary disruption of the blood–brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques.” Cancer research 72.14 (2012): 3652-3663.



    Kinoshita, Manabu, et al. “Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption.” Proceedings of the National Academy of Sciences 103.31 (2006): 11719-11723.



    Relevant Review Papers


    O’Reilly, Meaghan A., and Kullervo Hynynen. “Ultrasound enhanced drug delivery to the brain and central nervous system.” International Journal of Hyperthermia 28.4 (2012): 386-396.

    Portable Water Degassing System
    The LP-100 Focused Ultrasound System requires the use of degassed and deionized water. The FUS-DS-50 Water Degassing System is a portable unit that can quickly produce degassed water on demand. The device can be easily stored away and comes with all the required tubing and accessories to facilitate focused ultrasound research.
    Precisely Calibrated Focused Ultrasound Transducers
    These precise, spherically focused ultrasound transducers are highest quality available. They are fully customizable and come in a wide rage of frequencies (250KHz to 3MHz) for your specific application. Please contact us with your specific needs and we would be happy to develop a transducer that is right for you.
    MRI RF Imaging Coils
    These waterproof coils are designed to fit within the LP100 and RK300 systems and they have a built-in acoustic window. For the LP100, rodent and large animal sizes are available.
    Image Guided Targeting Software
    The image guidance software enables simple point-and-click targeting for sonications. Targets can be prescribed as single points or as line, raster, or circular patterns. 
    Animal Restraint and Anesthesia Hookup
    This MR-compatible holder is a robust device for repeatably and reliably holding small animals for experiments. The holder also contains a heating pad, allowing scientists to maintain an animal’s temperature during experiments