focused ultrasound system,台式聚焦超声血脑屏障系统

品牌:fus instruments


Bench-top focused ultrasound



The focused ultrasound system that enables targeted brain exposures without the need for concurrent imaging.
The RK-50 is a stand-alone, versatile, preclinical system designed to take advantage of the various applications of focused ultrasound. Through the use of traditional stereotaxic targeting methods, the RK-50 can deliver precise doses of FUS through an intact skull to small structures in the rodent brain. The system can also be used to automatically raster a series of FUS exposures to cover an arbitrary volume. Applications include ablation, blood-brain barrier disruption, and neuromodulation.
  • Precise, fast targeting with 3-axis positioning system
  • Treatment planning software facilitates stereotaxic-guided target selection and exposure control (runs on included PC)
  • Multi-point targeting is achievable in line, raster, and circular exposures
  • Focused ultrasound dose settings can be easily controlled for any application
  • Utilizes calibrated focused ultrasound transducers, available in a range of frequencies
  • Studies using FUS Instruments’ Systems

    Moyer, Linsey C., et al. “High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles.” Journal of Therapeutic Ultrasound 3.1 (2015): 7.

    Ellens, N. P. K., et al. “The targeting accuracy of a preclinical MRI-guided focused ultrasound system.” Medical physics 42.1 (2015): 430-439.

    Burgess, Alison, et al. “Alzheimer disease in a mouse model: MR imaging–guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior.”Radiology 273.3 (2014): 736-745.

    Diaz, Roberto Jose, et al. “Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: Potential for targeting experimental brain tumors.” Nanomedicine: Nanotechnology, Biology and Medicine 10.5 (2014): 1075-1087.

    Nance, Elizabeth, et al. “Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood? brain barrier using MRI-guided focused ultrasound.” Journal of Controlled Release 189 (2014): 123-132.

    Oakden, Wendy, et al. “A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles.” Journal of neuroscience methods 235 (2014): 92-100.
    Phillips, Linsey C., et al. “Dual perfluorocarbon nanodroplets enhance high intensity focused ultrasound heating and extend therapeutic window in vivo.” The Journal of the Acoustical Society of America 134.5 (2013): 4049-4049.
    Alkins, Ryan D., et al. “Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound.” Neuro-oncology (2013): not052.

    Alkins, Ryan, et al. “Focused ultrasound delivers targeted immune cells to metastatic brain tumors.” Cancer research 73.6 (2013): 1892-1899.

    Huang, Yuexi, Natalia I. Vykhodtseva, and Kullervo Hynynen. “Creating brain lesions with low-intensity focused ultrasound with microbubbles: a rat study at half a megahertz.” Ultrasound in medicine & biology 39.8 (2013): 1420-1428.

    Jord?o, Jessica F., et al. “Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound.” Experimental neurology 248 (2013): 16-29.

    Scarcelli, Tiffany, et al. “Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice.” Brain stimulation 7.2 (2013): 304-307.

    Etame, Arnold B., et al. “Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound.” Nanomedicine: Nanotechnology, Biology and Medicine 8.7 (2012): 1133-1142.


    Thévenot, Emmanuel, et al. “Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound.” Human gene therapy 23.11 (2012): 1144-1155.


    Staruch, Robert, Rajiv Chopra, and Kullervo Hynynen. “Hyperthermia in Bone Generated with MR Imaging–controlled Focused Ultrasound: Control Strategies and Drug Delivery.” Radiology 263.1 (2012): 117-127.


    Burgess, Alison, et al. “Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier.” PLoS One 6.11 (2011): e27877.


    Jord?o, Jessica F., et al. “Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-β plaque load in the TgCRND8 mouse model of Alzheimer’s disease.” PloS one 5.5 (2010): e10549.


    Blood-Brain Barrier Disruption Studies

    Leinenga, Gerhard, and Jürgen G?tz. “Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model.” Science translational medicine 7.278 (2015): 278ra33-278ra33.


    Wang, S., et al. “Noninvasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virus.” Gene Therapy 22.1 (2015): 104-110.


    McDannold, Nathan, et al. “Temporary disruption of the blood–brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques.” Cancer research 72.14 (2012): 3652-3663.


    Treat, Lisa H., et al. “Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma.” Ultrasound in medicine & biology 38.10 (2012): 1716-1725.

    Kinoshita, Manabu, et al. “Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption.” Proceedings of the National Academy of Sciences 103.31 (2006): 11719-11723.


    Kinoshita, Manabu, et al. “Targeted delivery of antibodies through the blood–brain barrier by MRI-guided focused ultrasound.” Biochemical and biophysical research communications 340.4 (2006): 1085-1090.

    Relevant Review Papers

    Burgess, Alison, and Kullervo Hynynen. “Drug delivery across the blood-brain barrier using focused ultrasound.”Expert opinion on drug delivery 11.5 (2014): 711-721.


    O’Reilly, Meaghan A., and Kullervo Hynynen. “Ultrasound enhanced drug delivery to the brain and central nervous system.” International Journal of Hyperthermia 28.4 (2012): 386-396.