Background
Histone H3 along with H2A, H2B and H4 is involved in the structure of chromatin in eukaryotic cells. Histone H3 can undergo several different types of epigenetic modifications that influence cellular processes. These modifications, including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation, occur on the N-terminal tail domains of histone H3, which results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. In most species, histone H3 is primarily acetylated at lysine 9, 14, 18, and 23.

Description
Histone H3K23ac (Acetyl H3K23) Polyclonal Antibody. Unconjugated. Raised in: Rabbit

Uniprot ID
P68431, Q71DI3, P84243

Purification
Affinity Purified

Specificity
Human, Mouse, Rat

Isotype
IgG

Immunogen 
Synthesized peptide derived from human Histone H3 around the acetylation site of K23.

Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage
Shipped at 4°C. Store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Application 
WB: 1/500 - 1/2000
 IF: 1/200 - 1/1000
ELISA: 1/5000

Alternative Names
H3K23ac antibody, H3K23a antibody

VCU0006