产品名称XONA神经元轴突培养板——文献、PUBLICATIONS (using or citing Xona Microfluidics? devices/chips)
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PUBLICATIONS (using or citing Xona Microfluidics® devices/chips)

2022

Harbauer, A.B., Hees, J.T., Wanderoy, S., Segura, I., Gibbs, W., Cheng, Y., Ordonez, M., Cai, Z., Cartoni, R., Ashrafi, G., Wang, C., Perocchi, F., He, Z., Schwarz, T.L., 2022. Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron* uses Xona’s Silicone Devices (RD450) with rat hippocampal neurons

Badiola-Mateos, Maider and Osaki, Tatsuya and Kamm, Roger D. and Samitier, Josep, In vitro Modelling of Human Healthy and ALS Proprioceptive Sensory Neurons in the Neuromuscular System. Available at SSRNhttps://ssrn.com/abstract=4007585 or http://dx.doi.org/10.2139/ssrn.4007585

Lotlikar, M.S., Tarantino, M.B., Jorfi, M., Kovacs, D.M., Tanzi, R.E., Bhattacharyya, R., 2022. Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix. STAR Protocols 3, 101028. * uses XonaChips® (XC150, XC450) with human NPCs cultured in 3D using Matrigel®

Yin, Q., Sun, L., Cai, X., Lou, F., Sun, Y., Wang, B., Jiang, B., Bao, L., Li, X., Song, N., Tang, S., Bai, J., Wang, Z., Wu, Y., Zhou, H., Wang, H., Yu, B., Li, Q., Wang, H., 2022. Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling-Mediated Sensory Neuron-Dendritic Cell Communication. Journal of Investigative Dermatology.

He, Q.-R., Cong, M., Yu, F.-H., Ji, Y.-H., Yu, S., Shi, H.-Y., Ding, F., 2022. Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons. Neural Regeneration Research 17, 1833-1840. * uses Xona’s Silicone Devices (SND150)

Lee, S., Park, D., Lim, C., Kim, J.-I., Min, K.-T., 2022. mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth. BMC Biology 20, 12. https://doi.org/10.1186/s12915-021-01215-w * uses Xona’s Silicone Devices (RD150)

Danastas, K., Larsen, A., Jobson, S., Guo, G., Cunningham, A.L., Miranda-Saksena, M., 2022. Herpes simplex virus-1 utilizes the host actin cytoskeleton for its release from axonal growth cones. PLOS Pathogens 18, e1010264. * uses Xona’s Silicone Devices (SND450) with rat DRG neurons

Limone, F., Mitchell, J.M., San Juan, I.G., Smith, J.L.M., Raghunathan, K., Couto, A., Ghosh, S.D., Meyer, D., Mello, C.J., Nemesh, J., Smith, B.M., McCarroll, S., Pietil?inen, O., Nehme, R., Eggan, K., 2022. Efficient generation of lower induced Motor Neurons by coupling <em>Ngn2</em> expression with developmental cues. bioRxiv, 2022.2001.2012.476020. * uses XonaChips® (XC450)

2021

Stoklund Dittlau, K., Krasnow, E.N., Fumagalli, L., Vandoorne, T., Baatsen, P., Kerstens, A., Giacomazzi, G., Pavie, B., Rossaert, E., Beckers, J., Sampaolesi, M., Van Damme, P., Van Den Bosch, L., 2021. Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices. JoVE, e62959. * uses XonaChips® (XC150) and Xona’s Silicone Devices (SND75) with human iPSC-differentiated motor neurons and human mesoangioblasts (MAB)-derived myotubes to create in vitro NMJs.

Stoklund Dittlau, K., Krasnow, E.N., Fumagalli, L., Vandoorne, T., Baatsen, P., Kerstens, A., Giacomazzi, G., Pavie, B., Rossaert, E., Beckers, J., Sampaolesi, M., Van Damme, P., Van Den Bosch, L., 2021. Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Reports 16, 2213-2227. https://doi.org/10.1016/j.stemcr.2021.03.029 * uses XonaChips® (XC150) and Xona’s Silicone Devices (SND75) with human iPSC-differentiated motor neurons and human mesoangioblasts (MAB)-derived myotubes to create in vitro NMJs.

Liu, M., Pi, H., Xi, Y., Wang, L., Tian, L., Chen, M., Xie, J., Deng, P., Zhang, T., Zhou, C., Liang, Y., Zhang, L., He, M., Lu, Y., Chen, C., Yu, Z., Zhou, Z., 2021. KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy 17, 903-924. https://doi.org/10.1080/15548627.2020.1739444 * uses Xona’s Silicone Devices (SND450)

van Erp, S., van Berkel, A.A., Feenstra, E.M., Sahoo, P.K., Wagstaff, L.J., Twiss, J.L., Fawcett, J.W., Eva, R., ffrench-Constant, C., 2021. Age-related loss of axonal regeneration is reflected by the level of local translation. Exp Neurol 339, 113594. https://doi.org/10.1016/j.expneurol.2020.113594 * uses Xona’s Silicone Devices (RD450) with hESC-differentiated neurons.

Lie, P.P.Y., Yang, D.-S., Stavrides, P., Goulbourne, C.N., Zheng, P., Mohan, P.S., Cataldo, A.M., Nixon, R.A., 2021. Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons. Cell Rep 35, 109034. https://doi.org/10.1016/j.celrep.2021.109034 * uses Xona’s Silicone Devices (RD450) with embryonic mouse cortical neurons. 

Fligor, C.M., Lavekar, S.S., Harkin, J., Shields, P.K., VanderWall, K.B., Huang, K.-C., Gomes, C., Meyer, J.S., 2021. Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2021.05.009 * uses XonaChips® (XC450) with hPSC-derived retinal ganglion neurons (RGCs) purified from retinal organoids

Güner, F., Pozner, T., Krach, F., Prots, I., Loskarn, S., Schl?tzer-Schrehardt, U., Winkler, J., Winner, B., Regensburger, M., 2021. Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Frontiers in Neuroscience 15. https://doi.org/10.3389/fnins.2021.680572 * uses Xona’s Silicone Devices (SND450) with human iPSC-differentiated motor neuron progenitors and human cerebellar astrocytes co-cultures. 

Li, Yihang and Pazyra-Murphy, Maria F. and Avizonis, Daina and de Sa Tavares Russo, Mariana and Tang, Sophia and Bergholz, Johann S. and Jiang, Tao and Zhao, Jean J. and Zhu, Jian and Ko, Kwang Woo and Milbrandt, Jeffrey and DiAntonio, Aaron and Segal, Rosalind A., Activation of Sarm1 Produces cADPR to Increase Intra-Axonal Calcium and Promote Axon Degeneration in CIPN. Available at SSRN: https://ssrn.com/abstract=3830010 or http://dx.doi.org/10.2139/ssrn.3830010 * uses XonaChips® (XC900)

Bhattacharyya, R., Black, S.E., Lotlikar, M.S., Fenn, R.H., Jorfi, M., Kovacs, D.M., Tanzi, R.E., 2021. Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes. Cell Rep 35, 109134. https://doi.org/10.1016/j.celrep.2021.109134 * uses XonaChips® (XC150, XC450) with human NPCs cultured in 3D using Matrigel®

Akin, E.J., Alsaloum, M., Higerd, G.P., Liu, S., Zhao, P., Dib-Hajj, F.B., Waxman, S.G., Dib-Hajj, S.D., 2021. Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7. Brain. https://doi.org/10.1093/brain/awab113 * uses Xona’s Silicone Devices (DOC450) with rat DRG neurons 

Katiyar, N., Raju, G., Madhusudanan, P., Gopalakrishnan-Prema, V., Shankarappa, S.A., 2021. Neuronal delivery of nanoparticles via nerve fibres in the skin. Sci Rep 11, 2566. https://doi.org/10.1038/s41598-021-81995-x * uses Xona’s Silicone Devices (SND150) with adult rat DRG neurons 

Zhang, Y., Li, C., Qin, Y., Cepparulo, P., Millman, M., Chopp, M., Kemper, A., Szalad, A., Lu, X., Wang, L., Zhang, Z.G., 2021. Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer. Journal of Extracellular Vesicles 10, e12073. https://doi.org/10.1002/jev2.12073 * uses Xona’s Silicone Devices (SND150) with mouse adult DRG neurons 

Pal, A., Kretner, B., Abo-Rady, M., Glaβ, H., Dash, B.P., Naumann, M., Japtok, J., Kreiter, N., Dhingra, A., Heutink, P., B?ckers, T.M., Günther, R., Sterneckert, J., Hermann, A., 2021. Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis. Life Science Alliance 4, e202000764. http://doi.org/10.26508/lsa.202000764 * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons

Dauer née Joppe, K., Tatenhorst, L., Caldi Gomes, L., Zhang, S., Parvaz, M., Carboni, E., Roser, A.-E., El DeBakey, H., B?hr, M., Vogel-Miku?, K., Wang Ip, C., Becker, S., Zweckstetter, M., Lingor, P., 2021. Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils. J Neurochem 159, 554-573.

Cai, E., Cheng, Q., Yu, S., Ding, F., 2021. Achyranthes bidentata polypeptide k enhances the survival, growth and axonal regeneration of spinal cord motor neurons in vitro. NeuroReport 32.

Siddiq, M.M., Hannila, S.S., Zorina, Y., Nikulina, E., Rabinovich, V., Hou, J., Huq, R., Richman, E.L., Tolentino, R.E., Hansen, J., Velenosi, A., Kwon, B.K., Tsirka, S.E., Maze, I., Sebra, R., Beaumont, K.G., Toro, C.A., Cardozo, C.P., Iyengar, R., Filbin, M.T., 2021. Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration. Brain Communications, fcab271. * uses Xona’s Silicone Devices (SND150, SND450) with rat DRG neurons

Ha, T.-Y., Choi, Y.R., Noh, H.R., Cha, S.-H., Kim, J.-B., Park, S.M., 2021. Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons. Molecular Brain 14, 122. https://doi.org/10.1186/s13041-021-00834-2 * uses Xona’s Silicone Devices (TCND1000) with mouse cortical neurons and compartmentalized α-syn fibrils

Prox, J., Seicol, B., Qi, H., Argall, A., Araya, N., Behnke, N., Guo, L., 2021. Toward living neuroprosthetics: developing a biological brain pacemaker as a living neuromodulatory implant for improving parkinsonian symptoms. Journal of Neural Engineering 18, 046081.

Atmaramani, R., Veeramachaneni, S., Mogas, L.V., Koppikar, P., Black, B.J., Hammack, A., Pancrazio, J.J., Granja-Vazquez, R., 2021. Investigating the Function of Adult DRG Neuron Axons Using an In Vitro Microfluidic Culture System. Micromachines 12. * uses Xona’s Silicone Devices (SND150)

Bindas, A.J., Kulkarni, S., Koppes, R.A., Koppes, A.N., 2021. Parkinson’s disease and the gut: Models of an emerging relationship. Acta Biomaterialia 132, 325-344. Review

Lee, S., Park, D., Lim, C., Kim, J.-I., Min, K.-T., 2021. Local protein synthesis of mtIF3 regulates mitochondrial translation for axonal development. bioRxiv, 2021.2001.2026.428248. https://doi.org/10.1101/2021.01.26.428248 * uses Xona’s Silicone Devices (RD150) with mouse hippocampal neurons 

Marchi, P.M., Marrone, L., Brasseur, L., Bousset, L., Webster, C.P., Destro, M., Smith, E.F., Walther, C.G., Alfred, V., Marroccella, R., Robinson, D., Shaw, A.C., Wan, L.M., Grierson, A.J., Ebbens, S.J., De Vos, K.J., Hautbergue, G.M., Ferraiuolo, L., Melki, R., Azzouz, M., 2021. C9orf72-derived poly-GA DPRs undergo endocytic uptake in iNPC-derived astrocytes and spread to motor neurons. bioRxiv, 2021.2010.2011.463891.

Hao, J., Wells, M.F., Niu, G., San Juan, I.G., Limone, F., Fukuda, A., Leyton-Jaimes, M.F., Joseph, B., Qian, M., Mordes, D.A., Budnik, B., Dou, Z., Eggan, K., 2021. Loss of TBK1 activity leads to TDP-43 proteinopathy through lysosomal dysfunction in human motor neurons. bioRxiv, 2021.2010.2011.464011.

Margarita, D.C., Laura, C., Urszula, B., Amandine, G., Natalia, T.E., Isabelle, F., Hossain, I., Daniela, G., Anne, E., Matthias, M., Eline, P.-V., 2021. Mutant huntingtin actively crosses neuromuscular synapses and causes transmission-selective pathology in human myotubes. bioRxiv, 2021.2007.2028.454044.

Mao, X., Gu, H., Kim, D., Kimura, Y., Wang, N., Xu, E., Wang, H., Chen, C., Zhang, S., Jia, C., Liu, Y., Bian, H., Karuppagounder, S.S., Jia, L., Ke, X., Chang, M., Li, A., Yang, J., Rastegar, C., Sriparna, M., Ge, P., Brahmachari, S., Kim, S., Zhang, S., Shimoda, Y., Saar, M., Workman, C.J., Vignali, D.A.A., Muller, U.C., Liu, C., Ko, H.S., Dawson, V.L., Dawson, T.M., 2021. Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic α-synuclein. bioRxiv, 2021.2005.2001.442157.

Harbauer, A.B., Wanderoy, S., Hees, J.T., Gibbs, W., Ordonez, M., Cai, Z., Cartoni, R., Ashrafi, G., Wang, C., He, Z., Schwarz, T.L., 2021. Neuronal mitochondria transport <em>Pink1</em> mRNA via Synaptojanin 2 to support local mitophagy. bioRxiv, 2021.2005.2019.444778. * uses Xona’s Silicone Devices (RD450) with rat hippocampal neurons

Brás, I.C., Khani, M.H., Riedel, D., Parfentev, I., Gerhardt, E., Christoph van, R., Urlaub, H., Gollisch, T., Outeiro, T.F., 2021. Ectosomes and exosomes are distinct proteomic entities that modulate spontaneous activity in neuronal cells. bioRxiv, 2021.2006.2024.449731. * uses Xona’s Silicone Devices (TCND1000) with mouse cortical neurons

Woldegebriel, R., Kvist, J., White, M., Sinkko, M., H?nninen, S., Sainio, M.T., Torregrosa-Munumer, R., Harjuhaahto, S., Huber, N., Herukka, S.-K., Haapasalo, A., Carpen, O., Bassett, A., Ylikallio, E., Sreedharan, J., Tyynismaa, H., 2021. Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons. bioRxiv, 2021.2005.2018.444636. * uses XonaChips® (XC450)

Loreto, A., Angeletti, C., Gu, W., Osborne, A., Nieuwenhuis, B., Gilley, J., Arthur-Farraj, P., Merlini, E., Amici, A., Luo, Z., Hartley-Tassell, L., Ve, T., Desrochers, L.M., Wang, Q., Kobe, B., Orsomando, G., Coleman, M.P., 2021. Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity. bioRxiv, 2020.2009.2018.304261.

Hofmann, M., Biller, L., Michel, U., B?hr, M., Koch, J.C., 2021. Cytoskeletal assembly in axonal outgrowth and regeneration analyzed on the nanoscale. bioRxiv, 2021.2011.2004.467310.

 

2020

Lomoio S, Willen R, Kim W, Ho KZ, Robinson EK, Prokopenko D, Kennedy ME, Tanzi RE, Tesco G., 2020. Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings. Sci Transl Med.  Nov 18;12(570):eaba1871. doi: 10.1126/scitranslmed.aba1871. PMID: 33208500. * uses Xona’s Silicone Devices (SND450) with mouse hippocampal neurons

Banh, R.S., Biancur, D.E., Yamamoto, K., Sohn, A.S.W., Walters, B., Kuljanin, M., Gikandi, A., Wang, H., Mancias, J.D., Schneider, R.J., Pacold, M.E., Kimmelman, A.C., 2020. Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer. Cell 183, 1202-1218.e1225. https://doi.org/10.1016/j.cell.2020.10.016 

Zhang, Y., Qin, Y., Chopp, M., Li, C., Kemper, A., Liu, X., Wang, X., Zhang, L., Zhang Zheng, G., 2020. Ischemic Cerebral Endothelial Cell–Derived Exosomes Promote Axonal Growth. Stroke 51, 3701-3712. 10.1161/STROKEAHA.120.031728 * uses Xona’s Silicone Devices (SND450, TCND500) with rat cortical neurons and exosomes isolated from cerebral endothelial cells (CECs)

Wu, Q., Shaikh, M.A., Meymand, E.S., Zhang, B., Luk, K.C., Trojanowski, J.Q., Lee, V.M.Y., 2020. Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathol 140, 831-849. 10.1007/s00401-020-02227-6

Yezid, Hocine; Lay, Christian T.; Pannhorst, Katrin; Chowdhury, Shafiqul I. 2020. “Two Separate Tyrosine-Based YXXL/Φ Motifs within the Glycoprotein E Cytoplasmic Tail of Bovine Herpesvirus 1 Contribute in Virus Anterograde Neuronal Transport” Viruses 12, no. 9: 1025. https://doi.org/10.3390/v12091025

Aravamudhan, P., Raghunathan, K., Dermody, T.S., 2020. Confocal Microscopy of Reovirus Transport in Living Dorsal Root Ganglion Neurons. Bio Protoc 10, e3825. 10.21769/BioProtoc.3825  * uses XonaChips® (XC450) with rat DRG neurons

Fujita, Y., Yamashita, T., 2020. Protocol for Co-culture of Microglia with Axons. STAR Protocols, 100111. https://doi.org/10.1016/j.xpro.2020.100111 * uses Xona’s Silicone Devices (SND450) with mouse co-cultures with cortical neurons and microglia

Watters, O., Connolly, N.M.C., K?nig, H.-G., Düssmann, H., Prehn, J.H.M., 2020. AMPK Preferentially Depresses Retrograde Transport of Axonal Mitochondria during Localized Nutrient Deprivation. The Journal of Neuroscience 40, 4798. 10.1523/JNEUROSCI.2067-19.2020 

Nagano, S., Jinno, J., Abdelhamid, R.F., Jin, Y., Shibata, M., Watanabe, S., Hirokawa, S., Nishizawa, M., Sakimura, K., Onodera, O., Okada, H., Okada, T., Saito, Y., Takahashi-Fujigasaki, J., Murayama, S., Wakatsuki, S., Mochizuki, H., Araki, T., 2020. TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons. Acta Neuropathol 140, 695-713. https://doi.org/10.1007/s00401-020-02205-y 

Mak, H.K., Yung, J.S.Y., Weinreb, R.N., Ng, S.H., Cao, X., Ho, T.Y.C., Ng, T.K., Chu, W.K., Yung, W.H., Choy, K.W., Wang, C.C., Lee, T.L., Leung, C.K., 2020. MicroRNA-19a-PTEN Axis Is Involved in the Developmental Decline of Axon Regenerative Capacity in Retinal Ganglion Cells. Mol Ther Nucleic Acids 21, 251-263.* uses Xona’s Silicone Devices (RD450) with mouse retinal ganglion cells

Soleilhavoup, C., Travaglio, M., Patrick, K., Garcao, P., Boobalan, E., Adolfs, Y., Spriggs, R.V., Moles-Garcia, E., Dhiraj, D., Oosterveen, T., Ferri, S.L., Abel, T., Brodkin, E.S., Pasterkamp, R.J., Brooks, B.P., Panman, L., 2020. Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun 11, 3111. * uses Xona’s Silicone Devices (SND900) with mouse midbrain and striatum co-cultures 

Abo-Rady, M., Kalmbach, N., Pal, A., Schludi, C., Janosch, A., Richter, T., Freitag, P., Bickle, M., Kahlert, A.K., Petri, S., Stefanov, S., Glass, H., Staege, S., Just, W., Bhatnagar, R., Edbauer, D., Hermann, A., Wegner, F., Sterneckert, J.L., 2020. Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins. Stem Cell Reports 14, 390-405. * uses Xona’s Silicone Devices  with human iPSC-differentiated motor neurons

Sundaramoorthy, V., Godde, N., Farr, R.J., Green, D., Haynes, J.M., Bingham, J., O’Brien, C.M., Dearnley, M., 2020. Modelling Lyssavirus Infections in Human Stem Cell-Derived Neural Cultures. Viruses 12. * uses Xona’s Silicone Devices (SND150) with human iPSC-differentiated neurons

Danastas, K., Cunningham, A.L., Miranda-Saksena, M., 2020. The Use of Microfluidic Neuronal Devices to Study the Anterograde Axonal Transport of Herpes Simplex Virus-1. Methods Mol Biol 2060, 409-418.

Cornejo, V.H., Gonzalez, C., Campos, M., Vargas-Saturno, L., Juricic, M.L.A., Miserey-Lenkei, S., Pertusa, M., Madrid, R., Couve, A., 2020. Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing. Cell Rep 30, 4505-4517 e4505. * uses Xona’s Silicone Devices with mouse trigeminal and DRG neurons

Leit?o, L., Neto, E., Concei??o, F., Monteiro, A., Couto, M., Alves, C.J., Sousa, D.M., Lamghari, M., 2020. Osteoblasts are inherently programmed to repel sensory innervation. Bone Research 8, 20. https://doi.org/10.1038/s41413-020-0096-1 * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons co-cultured with human mesenchymal stem cells (MSC)-differentiated osteoblasts

Aravamudhan, P., Raghunathan, K., Konopka-Anstadt, J., Pathak, A., Sutherland, D.M., Carter, B.D., Dermody, T.S., 2020. Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons. PLoS pathogens 16, e1008380-e1008380. PMID: 32109948 * uses XonaChips® (XC450) with rat DRG neurons

Fujita, Y., Nakanishi, T., Ueno, M., Itohara, S., Yamashita, T., 2020. Netrin-G1 Regulates Microglial Accumulation along Axons and Supports the Survival of Layer V Neurons in the Postnatal Mouse Brain. Cell Rep 31, 107580. https://doi.org/10.1016/j.celrep.2020.107580 * uses Xona’s Silicone Devices (SND450) with mouse cortical neurons co-cultured with microglia

Wang, T., Li, W., Martin, S., Papadopulos, A., Joensuu, M., Liu, C., Jiang, A., Shamsollahi, G., Amor, R., Lanoue, V., Padmanabhan, P., Meunier, F.A., 2020. Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability. Journal of Cell Biology 219. https://doi.org/10.1083/jcb.201902001 * uses Xona’s Silicone Devices (RD450 and TCND500) with rat hippocampal neurons

Fukuda, Y., Pazyra-Murphy, M.F., Silagi, E.S., Tasdemir-Yilmaz, O.E., Li, Y., Rose, L., Yeoh, Z.C., Vangos, N.E., Geffken, E.A., Seo, H.-S., Adelmant, G., Bird, G.H., Walensky, L.D., Marto, J.A., Dhe-Paganon, S., Segal, R.A., 2020. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. Journal of Cell Biology 220. https://doi.org/10.1083/jcb.202005051 * uses XonaChips® (XC900), XonaPDL?, and Xona’s Silicone Devices (SND450) with rat DRG neurons

Cristiano Lucci, Raquel Mesquita-Ribeiro, Alex Rathbone, Federico Dajas-Bailador (2020). Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons. Development 147: dev180232 doi: 10.1242/dev.180232 * uses Xona’s Silicone Devices (SND150) with mouse cortical neurons

Sundaramoorthy V, Green D, Locke K, O’Brien CM, Dearnley M, et al. (2020) Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies. PLOS Pathogens 16(2): e1008343. https://doi.org/10.1371/journal.ppat.1008343 * uses Xona’s Silicone Devices (SND450) with mouse cortical and DRG neurons

 

2019

Tian, N., Hanson, K.A., Canty, A.J., Vickers, J.C., King, A.E., 2020. Microtubule-dependent processes precede pathological calcium influx in excitotoxin-induced axon degeneration. J Neurochem 152, 542-555. https://doi.org/10.1111/jnc.14909 * uses Xona’s Silicone Devices (SND450) with mouse cortical neurons

Teotia, P., Van Hook, M.J., Fischer, D., Ahmad, I., 2019. Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway. Development 146, dev178012. doi: 10.1242/dev.178012 * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells

Gruner, H.N., Bae, B., Lynch, M., Oliver, D., So, K., Mastick, G.S., Yan, W., Miura, P., 2019. Precise removal of Calm1 long 3′ UTR isoform by CRISPR-Cas9 genome editing impairs dorsal root ganglion development in mice. bioRxiv, 553990. https://doi.org/10.1101/553990 * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons

Goto-Silva, L., McShane, M.P., Salinas, S., Kalaidzidis, Y., Schiavo, G., Zerial, M., 2019. Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome. Sci Rep 9, 2433. https://doi.org/10.1038/s41598-019-38637-0 * uses Xona’s Silicone Devices (cat # not specified) with rat DRG neurons

Barber, A.C., Evans, R.S., Nieuwenhuis, B., Pearson, C.S., Fuchs, J., MacQueen, A.R., Erp, S.v., Haenzi, B., Hulshof, L.A., Osborne, A., Conceicao, R., Deshpande, S.S., Cave, J., ffrench-Constant, C., Smith, P.D., Okkenhaug, K., Eickholt, B.J., Martin, K.R., Fawcett, J.W., Eva, R., 2019. PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS. bioRxiv, 787994. doi: https://doi.org/10.1101/787994 * uses Xona’s Silicone Devices (SND150) with rat DRG neurons

Nijssen, J., Aguila, J. and Hedlund, E. (2019). Axon-seq for in Depth Analysis of the RNA Content of Neuronal Processes. Bio-protocol 9(14): e3312. DOI: 10.21769/BioProtoc.3312. * uses Xona’s Silicone Devices (SND150, SND450, SND900) with mouse and human stem cell derived motor neurons

Shekari, A. & Fahnestock, M. (2019). Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons. Neurobiol. Aging, 84: 131-140, https://doi.org/10.1016/j.neurobiolaging.2019.07.018 * uses XonaChips® (XC450) with rat basal forebrain or cortical neurons

Vysokov, N., McMahon, S.B., Raouf, R., 2019. The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform. Sci Rep 9, 12915. DOI: 10.1038/s41598-019-49214-w * uses Xona’s Silicone Devices (TCND1000) with rat DRG neurons and dorsal horn co-culture

Nagendran, T. & Taylor, A.M. (2019). Unique Axon-to-Soma Signaling Pathways Mediate Dendritic Spine Loss and Hyper-Excitability Post-axotomy. Front. Cell. Neurosci., 13(431), https://doi.org/10.3389/fncel.2019.00431 * uses Silicone Devices (SND900) with rat hippocampal neurons **Original research authored by Xona scientists**

Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J. (2019). Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?. Viruses12(1), 14. https://doi.org/10.3390/v12010014 * uses XonaChips® (XC150) with murine mixed neurons

Hixon, A. M., Clarke, P., & Tyler, K. L. (2019). Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid. Journal of virology93(16), e00578-19. https://doi.org/10.1128/JVI.00578-19 * uses Xona’s Silicone Devices (RD450) with human iPSC-derived motor neurons

Yan, K., Liu, J., Guan, X., Yin, Y. X., Peng, H., Chen, H. C., & Liu, Z. F. (2019). The Carboxyl Terminus of Tegument Protein pUL21 Contributes to Pseudorabies Virus Neuroinvasion. Journal of virology, 93(7), e02052-18. https://doi.org/10.1128/JVI.02052-18 * uses Xona’s Silicone Devices (SND450) with chicken DRG neurons

Paranjape, S. R., Nagendran, T., Poole, V., Harris, J., Taylor, A. M. (2019). Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips J. Vis. Exp. (147), e59250, doi:10.3791/59250 (2019). * uses XonaChips® (XC150, XC450, XC900) with human stem cell derived glutamatergic neurons **authored by Xona scientists

Pu, H., Shi, Y., Zhang, L., Lu, Z., Ye, Q., Leak, R.K., Xu, F., Ma, S., Mu, H., Wei, Z., Xu, N., Xia, Y., Hu, X., Hitchens, T.K., Bennett, M.V.L., Chen, J., 2019. Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke. Proceedings of the National Academy of Sciences 116, 9115, doi: 10.1073/pnas.1821979116.* uses Xona’s Silicone Devices (SND450) with rat cortical neurons

Zheng, Y., Zhang, X., Wu, X., Jiang, L., Ahsan, A., Ma, S., Xiao, Z., Han, F., Qin, Z.-H., Hu, W., Chen, Z., 2019. Somatic autophagy of axonal mitochondria in ischemic neurons. The Journal of cell biology 218, 1891-1907. doi: 10.1083/jcb.201804101 * uses Xona’s Silicone Devices (RD450) with mouse cortical neurons

Kamande, J.W., Nagendran, T., Harris, J., Taylor, A.M., 2019. Multi-compartment Microfluidic Device Geometry and Covalently Bound Poly-D-Lysine Influence Neuronal Maturation. Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2019.00084. * uses Xona’s Silicone Devices (SND450, DOC450) with human stem cell derived glutamatergic neurons **Original research authored by Xona scientists**

Bieri, G., Brahic, M., Bousset, L., Couthouis, J., Kramer, N.J., Ma, R., Nakayama, L., Monbureau, M., Defensor, E., Schüle, B., Shamloo, M., Melki, R., Gitler, A.D., 2019. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.  Acta Neuropathol. 2019 Mar 29. doi: 10.1007/s00401-019-01995-0. * uses Xona’s Silicone Devices (SND450) with human stem cell derived neurons

Wang, L., Chopp, M., Lu, X., Szalad, A., Jia, L., Liu, X.S., Wu, K.-H., Lu, M., Zhang, Z.G., 2019. miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice. 
Brain Res. Mar 15;1707:198-207. doi: 10.1016/j.brainres.2018.11.039 * uses Xona’s Silicone Devices (Cat. # not specified) with rat DRG neurons

Zhu, S., Zhu, J., Zhen, G., Hu, Y., An, S., Li, Y., Zheng, Q., Chen, Z., Yang, Y., Wan, M., Skolasky, R.L., Cao, Y., Wu, T., Gao, B., Yang, M., Gao, M., Kuliwaba, J., Ni, S., Wang, L., Wu, C., Findlay, D., Eltzschig, H.K., Ouyang, H.W., Crane, J., Zhou, F.-Q., Guan, Y., Dong, X., Cao, X., 2019. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest. 2019 Mar 1;129(3):1076-1093. doi: 10.1172/JCI121561 * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons

Klim, J.R., Williams, L.A., Limone, F., Guerra San Juan, I., Davis-Dusenbery, B.N., Mordes, D.A., Burberry, A., Steinbaugh, M.J., Gamage, K.K., Kirchner, R., Moccia, R., Cassel, S.H., Chen, K., Wainger, B.J., Woolf, C.J., Eggan, K., 2019. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat Neurosci. Feb;22(2):167-179. doi: 10.1038/s41593-018-0300-4. * uses Xona’s Silicone Devices (SND150) with human stem cell (iPSC and ESC) derived motor neurons

Fantuzzo, J.A., Hart, R.P., Zahn, J.D., Pang, Z.P., 2019. Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics. Dev Dyn 248, 65-77. doi: 10.1002/dvdy.2466 * Review paper

Li, C., Zhang, Y., Levin, A.M., Fan, B.Y., Teng, H., Ghannam, M.M., Chopp, M., Zhang, Z.G., 2019. Distal Axonal Proteins and Their Related MiRNAs in Cultured Cortical Neurons. Mol Neurobiol. Apr;56(4):2703-2713. doi: 10.1007/s12035-018-1266-7. * uses Xona’s Silicone Devices (SND450) with rat cortical neurons

2018

Naumann, M., Pal, A., Goswami, A., Lojewski, X., Japtok, J., Vehlow, A., Naujock, M., Günther, R., Jin, M., Stanslowsky, N., Reinhardt, P., Sterneckert, J., Frickenhaus, M., Pan-Montojo, F., Storkebaum, E., Poser, I., Freischmidt, A., Weishaupt, J.H., Holzmann, K., Troost, D., Ludolph, A.C., Boeckers, T.M., Liebau, S., Petri, S., Cordes, N., Hyman, A.A., Wegner, F., Grill, S.W., Weis, J., Storch, A., Hermann, A., 2018. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. Nature Communications 9, 335. https://doi.org/10.1038/s41467-017-02299-1 * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons

Nijssen, J., Aguila, J., Hoogstraaten, R., Kee, N., Hedlund, E., 2018. Axon-Seq Decodes the Motor Axon Transcriptome and Its Modulation in Response to ALS. Stem Cell Reports 11, 1565-1578.

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons
Nagendran, T., Poole, V., Harris, J., Taylor, A. M. Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons. J. Vis. Exp. (141), e58421, doi:10.3791/58421 (2018).

Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson’s Disease-Relevant Stress.
J Neurosci. 2018 Aug 22;38(34):7505-7515. doi: 10.1523/JNEUROSCI.0541-18.2018. Epub 2018 Jul 20.

Exosomes derived from high-glucose-stimulated Schwann cells promote development of diabetic peripheral neuropathy.
FASEB J. 2018 Jun 22:fj201800597R. doi: 10.1096/fj.201800597R. [Epub ahead of print]

Microfluidics of Small-Population Neurons Allows for a Precise Quantification of the Peripheral Axonal Growth State
Front Cell Neurosci. 2018; 12: 166. June 15, 2018

Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering.
Biomaterials. 2018 May 11. pii: S0142-9612(18)30347-8. doi: 10.1016/j.biomaterials.2018.05.012. [Epub ahead of print]

MiR-34a Regulates Axonal Growth of Dorsal Root Ganglia Neurons by Targeting FOXP2 and VAT1 in Postnatal and Adult Mouse.
Mol Neurobiol. 2018 Apr 10. doi: 10.1007/s12035-018-1047-3. [Epub ahead of print]

Neuronal subtype determines HSV-1 Latency-Associated-Transcript (LAT) promoter activity during latency.
J Virol. 2018 Apr 11. pii: JVI.00430-18. doi: 10.1128/JVI.00430-18. [Epub ahead of print]

Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury.
Neuroscience. 2018 Apr 1;375:34-48. doi: 10.1016/j.neuroscience.2018.02.003. Epub 2018 Feb 10.

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons.
Acta Neuropathol Commun. 2018 Feb 15;6(1):10. doi: 10.1186/s40478-018-0514-4.

Neurturin is a PGC-1a1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation.
Mol Metab. 2018 Jan;7:12-22. doi: 10.1016/j.molmet.2017.11.001. Epub 2017 Nov 7.

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.
PLoS Pathog. 2018 Jan 5;14(1):e1006823. doi: 10.1371/journal.ppat.1006823. eCollection 2018 Jan.

Visualization of local phosphatidylcholine synthesis within hippocampal neurons using a compartmentalized culture system and imaging mass spectrometry
Biochem Biophys Res Commun. 2018 Jan 1;495(1):1048-1054. doi: 10.1016/j.bbrc.2017.11.108. Epub 2017 Nov 21.

Intercellular transfer of pathogenic a-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal
Neurobiol Aging. 2018 Jan;61:52-65. doi: 10.1016/j.neurobiolaging.2017.09.016. Epub 2017 Sep 22.

2017

Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nat Commun. 2017 Sep 20;8(1):625. **Original research authored by Xona scientists**

Microfluidic Device for Studying Traumatic Brain Injury
Part of the Neuromethods book series (NM, volume 126) First Online: 12 May 2017

Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse 
PLoS One. 2017; 12(5): e0176997. Published online 2017 May 4.

Using high-throughput barcode sequencing to efficiently map connectomes
Nucleic Acids Res. 2017 Jul 7. 45(12): e115. Published online 2017 Apr 26

Messenger RNAs localized to distal projections of human stem cell derived neurons.
Sci Rep 7. 2017 Apr 4;7(1):611. Published online

NGF-dependent axon growth and regeneration are altered in sympathetic neurons of dystrophic mdx mice.
Mol Cell Neurosci. 2017 Feb 2;80:1-17 [Epub ahead of print]

T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signaling Open Biology. Published 18 January 2017.DOI: 10.1098/rsob.160288

The release and trans-synaptic transmission of Tau via exosomes
Mol Neurodegener. 2017; 12: 5. Published online 2017 Jan 13.

MiR-29c/PRKCI Regulates Axonal Growth of Dorsal Root Ganglia Neurons Under Hyperglycemia.
Mol Neurobiol. 2017 Jan 9. [Epub ahead of print]

Co-culture Synaptogenic Assay: A New Look at Fluorescence Reporters and Technological Devices.
Methods Mol Biol. 2017;1538:13-27qua

2016

Acetylated tubulin is essential for touch sensation in mice 
eLife. 2016; 5: e20813. Published online 2016 Dec 13

Mesenchymal Stromal Cells Promote Axonal Outgrowth Alone and Synergistically with Astrocytes via tPA 
PLoS One. 2016; 11(12): e0168345. Published online 2016 Dec 13.

Compartmentalized Microfluidic Platforms: The Unrivaled Breakthrough of In Vitro Tools for Neurobiological Research.
J Neurosci. 2016 Nov 16;36(46):11573-11584.

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 
Science. 2016 Sep 30; 353(6307): aah3374.

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease 
Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): E5655–E5664. Published online 2016 Sep 6.

Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons.
Cell Rep. 2016 Aug 16;16(7):1974-87. doi: 10.1016/j.celrep.2016.06.104. Epub 2016 Aug 4.

Probing extracellular Sonic hedgehog in neurons.
Biol Open. 2016 Aug 15;5(8):1086-92. doi: 10.1242/bio.019422.

Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons 
Sci Rep. 2016; 6: 31482. Published online 2016 Aug 11.

miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats.
Stem Cells Transl Med. 2016 Jul 26. pii: sctm.2015-0349. [Epub ahead of print]

Semaphorin 3C Released from a Biocompatible Hydrogel Guides and Promotes Axonal Growth of Rodent and Human Dopaminergic Neurons.
Tissue Eng Part A. 2016 Jun;22(11-12):850-61. doi: 10.1089/ten.TEA.2016.0008.

A New Defective Helper RNA to Produce Recombinant Sindbis Virus that Infects Neurons but does not Propagate
Front Neuroanat. 2016; 10: 56. Published online 2016 May 24. doi: 10.3389/fnana.2016.00056

Monitoring mRNA Translation in Neuronal Processes Using Fluorescent Non-Canonical Amino Acid Tagging.
J Histochem Cytochem. 2016 May;64(5):323-33. doi: 10.1369/0022155416641604. Epub 2016 Mar 29.

MicroRNA 146a locally mediates distal axonal growth of dorsal root ganglia neurons under high glucose and sildenafil conditions.
Neuroscience. 2016 Aug 4;329:43-53. doi: 10.1016/j.neuroscience.2016.05.005. Epub 2016 May 7.

Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain.
Elife. 2016 Apr 15;5. pii: e12151. doi: 10.7554/eLife.12151.

Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons.
Mol Neurobiol. 2016 Mar 19. [Epub ahead of print]

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability.
Nat Neurosci. 2016 May;19(5):690-6. doi: 10.1038/nn.4280. Epub 2016 Mar 28.

Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures 
J Neurosci Methods. 2016 Jun 15; 266: 32–41. Published online 2016 Mar 28.

Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport.
PLoS One. 2016 Jan 20;11(1):e0147250. doi: 10.1371/journal.pone.0147250. eCollection 2016.

Compartmentalized Platforms for Neuro-Pharmacological Research.
Curr Neuropharmacol. 2016;14(1):72-86.

D-4F Decreases White Matter Damage After Stroke in Mice
Stroke. 2016 Jan;47(1):214-20. doi: 10.1161/STROKEAHA.115.011046. Epub 2015 Nov 24.

2015

Dual Role of Herpes Simplex Virus 1 pUS9 in Virus Anterograde Axonal Transport and Final Assembly in Growth Cones in Distal Axons.
J Virol. 2015 Dec 23;90(5):2653-63. doi: 10.1128/JVI.03023-15.

The Basic Domain of Herpes Simplex Virus 1 pUS9 Recruits Kinesin-1 To Facilitate Egress from Neurons.
J Virol. 2015 Dec 9;90(4):2102-11. doi: 10.1128/JVI.03041-15.

Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation 
J Neurosci. 2015 Dec 9; 35(49): 16126–16141.

MicroRNAs in the axon locally mediate the effects of chondroitin sulfate proteoglycans and cGMP on axonal growth 
Dev Neurobiol. 2015 Dec; 75(12): 1402–1419. Published online 2015 Jun 24.

Whole transcriptome profiling reveals the RNA content of motor axons 
Nucleic Acids Res. 2016 Feb 29; 44(4): e33. Published online 2015 Oct 12.

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.  Cell Rep. 2015 May 26;11(8):1176-83

Morphometric assessment of toxicant induced neuronal degeneration in full and restricted contact co-cultures of embryonic cortical rat neurons and astrocytes: using m-Dinitrobezene as a model neurotoxicant. Toxicol In Vitro. 2015 Apr;29(3):564-74.

Coupled local translation and degradation regulate growth cone collapse 
Nat Commun. 2015; 6: 6888. Published online 2015 Apr 22.

Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a J Neurosci. 2015 Apr 15;35(15):6179-94

Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Front Behav Neurosci. 2015 Mar 11;9:62.

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity 
Dis Model Mech. 2015 Mar; 8(3): 215–224.

Recording large extracellular spikes in microchannels along many axonal sites from individual neurons. PLoS One. 2015 Mar 3;10(3):e0118514.

Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord. Cell Mol Life Sci. 2015 Feb 24.

A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379.

2014

Herpes simplex virus gE/gI extracellular domains promote axonal transport and spread from neurons to epithelial cells. J Virol. 2014 Oct;88(19):11178-86.

PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells. J Comp Neurol. 2014 Aug 15;522(12):2741-55.

A-synuclein immunotherapy blocks uptake and templated propagation of misfolded a-synuclein and neurodegeneration. Cell Rep. 2014 Jun 26;7(6):2054-65.

Regulation of axon growth by the JIP1-AKT axis. Dajas-Bailador F, Bantounas I, Jones EV, Whitmarsh AJ.  J Cell Sci. 2014 Jan 1;127(Pt 1):230-9.

2013

Probing functional properties of nociceptive axons using a microfluidic culture system.  PLoS One. 2013 Nov 20;8(11)

Microfluidic primary culture model of the lower motor neuron-neuromuscular junction circuit. J Neurosci Methods. 2013 Sep 15;218(2):164-9.

Dendritic GluN2A synthesis mediates activity-induced NMDA receptor insertion. J Neurosci. 2013 May 15;33(20):8898-908.

ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism. Development. 2013 May;140(10):2108-17.

The MicroRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical neurons. J Neurosci. 2013 Apr 17;33(16):6885-94.

Axonal translation of β-catenin regulates synaptic vesicle dynamics. J Neurosci. 2013 Mar 27;33(13):5584-9.

Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration. J Neurosci. 2013 Mar 20;33(12):5195-207.

Herpes simplex virus membrane proteins gE/gI and US9 act cooperatively to promote transport of capsids and glycoproteins from neuron cell bodies into initial axon segments. J Virol. 2013 Jan;87(1):403-14

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem. 2013 Jan 18;288(3):1856-70.

2012

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport. Ann Neurol. 2012 Oct;72(4):517-24.

Axonal outgrowth and dendritic plasticity in the cortical peri-infarct area after experimental stroke. Stroke. 2012 Aug;43(8):2221-8.

A herpes simplex virus 1 (McKrae) mutant lacking the glycoprotein K gene is unable to infect via neuronal axons and egress from neuronal cell bodies. MBio. 2012 Jul 24;3(4):e00144-12.

Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor. Genes Dev. 2012 Jul 15;26(14):1527-32.

Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms. Neuron. 2012 Jan 12;73(1):92-107.

Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model. ASN Neuro. 2012 Feb 23;4(1).

Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s). Chem Biol. 2012 Feb 24;19(2):179-87.

Microfluidics Platforms for Investigating Injury and Regeneration of CNS Axons. Ann Biomed Eng. 2012 Jun;40(6):1268-76.

2011

Microfluidic and Compartmentalized platforms for neurobiological research. Crit Rev Biomed Eng. 2011;39(3):185-200.

Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11246-51.

Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson’s disease. Cell Death Differ. 2012 Mar;19(3):416-27.

The bovine herpesvirus type 1 envelope protein Us9 acidic domain is crucial for anterograde axonal transport. Vet Microbiol. 2011 Sep 28;152(3-4):270-9.

IL-1β inhibits axonal growth of developing sympathetic neurons. Mol Cell Neurosci. 2011 Oct;48(2):142-50.

Micro-scale and microfluidic devices for neurobiology. Curr Opin Neurobiol. 2010 Oct;20(5):640-7.

Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection. Lab Chip. 2010 Aug 21;10(16):2083-92.

Anterograde transport of herpes simplex virus capsids in neurons by both Separate and Married mechanisms. J Virol. 2011 Jun;85(12):5919-28.

Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization. RNA. 2011 Jan;17(1):85-98.

Regulation of trafficking of activated TrkA is critical for NGF-mediated functions. Traffic. 2011 Apr;12(4):521-34.

2010

Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron. 2010 Apr 15;66(1):57-68.

2009

Shear stress effect on transfection of neurons cultured in microfluidic devices. J Nanosci Nanotechnol. 2009 Dec;9(12):7330-5.

Novel microfluidic platform for culturing neurons: culturing and biochemical analysis of neuronal components. Biotechnol J. 2009 Nov;4(11):1573-7.

Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein. Nat Cell Biol. 2009 Aug;11(8):1024-30.

beta-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging. 2011 May;32(5):821-33.

Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci. 2009 Apr 15;29(15):4697-707.

Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron. 2009 Mar 26;61(6):880-94.

2008

A microfluidic chamber for analysis of neuron-to-cell spread and axonal transport of an alpha-herpesvirus. PLoS One. 2008 Jun 18;3(6):e2382.

2006

Microfluidic chambers for cell migration and neuroscience research. Methods Mol Biol. 2006;321:167-77.

Microfluidic culture platform for neuroscience research. Nat Protoc. 2006;1(4):2128-36.

2005

A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods. 2005 Aug;2(8):599-605.

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