产品名称 TLR8 Antibody from DENDRITICS SAS
产品货号 DDX0483
产品价格 现货询价,电话:010-67529703
产品规格 100µg/50µg
产品品牌 DENDRITICS SAS
产品概述
产品详情
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Antigenic SpecificityTLR8
Clone112H7.15
Host SpeciesRat
Reactive Specieshuman
IsotypeIgG2a
Formatpurified
Size100µg/50µg
Concentrationn/a
ApplicationsIHC, WB, FACS intracyto
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe Toll-Like Receptors (TLRs) represent a family of germline-encoded proteins, composed of C-terminal leucine-rich repeats (LRRs), and an N-terminal Toll/Interleukin-1 Receptor (TIR) domain. In humans, 10 TLRs, sharing high sequence homology, have been identified. TLRs are critical for the detection of pathogen-associated molecular patterns (PAMPs) by the innate immune system. LRRs recognize PAMPs, and signal transduction events, initiated by the TIR domain, lead to activation of transcription factors such as AP-1, IRFs and NFkB, and therefore expression of proinflammatory cytokines and costimulatory molecules. TLR7, TLR8 and TLR9 form a subgroup in the TLR family, because of a strong sequence homology and the nature of their ligands, which are nucleic acids or related molecules. TLR7 and TLR8 are triggered by GU-rich, single-stranded RNA (ssRNA) derived from viruses, or by synthetic small molecules mimicking ssRNA, such as imidazoquinolines. While TLR7 is expressed in lung, placenta and spleen, TLR8 expression is restricted to lung and peripheral blood leukocytes (PBLs). Heil F. et al,2003 ,Eur.J.Immunol, 33, 2987)
Immunogenn/a
Other NamesToll-like receptor 8
Gene, Accession #n/a
Catalog #DDX0483
Price
Order / More InfoTLR8 Antibody from DENDRITICS SAS
Product Specific Referencesn/a
产品资料