产品名称 FOXP3 Antibody from BIOLEGEND
产品货号 320013
产品价格 现货询价,电话:010-67529703
产品规格 25 tests
产品品牌 BIOLEGEND
产品概述
产品详情
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Antigenic SpecificityFOXP3
Clone150D
Host SpeciesMouse
Reactive Specieshuman, mouse, rat, cross-reactivity: cynomolgus, rhesus, baboon
IsotypeIgG1, κ
FormatAlexa Fluor® 647 conjugate
Size25 tests
Concentrationn/a
ApplicationsIntracellular Staining for Flow Cytometry (ICFC)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionAlexa Fluor® 647 anti-mouse/rat/human FOXP3. FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.
ImmunogenFull-length FOXP3 protein
Other NamesForkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
Gene, Accession #Gene ID: 20371, 317382, 50943
Catalog #320013
Price
Order / More InfoFOXP3 Antibody from BIOLEGEND
Product Specific ReferencesPubMed: 16455959,17277168,18490467,18684977,19822646,19917773,20139272,24316007,24694524,25355918
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