产品名称 Recombinant Human IGFALS (carrier-free) from BIOLEGEND
产品货号 758802
产品价格 现货询价,电话:010-67529703
产品规格 10 µg
产品品牌 BIOLEGEND
产品概述
产品详情
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Product NameRecombinant Human IGFALS (carrier-free)
DescriptionThe insulin-like growth factors (IGFs) are found in binary complexes with members of IGF-binding protein family (IGFBP-1 to -6). IGFALS is the acid-labile subunit of the IGF binding protein complex that forms ternary complexes with IGFs and IGFBP-3/IGFBP-5. IGFALS has no affinity for free IGFs and has a very low affinity for uncomplexed IGFBP-3/IGFBP-5, but readily binds to the IGFs and IGFBP-3/IGFBP-5 complex, which extends the serum half-lives of IGFs. IGFALS is mainly produced by the liver and is exclusively found in high concentration in postnatal serum. IGFALS production is predominantly stimulated by the growth hormone. Mutations in IGFALS causes ALS, amyotrophic lateral sclerosis, deficiency, which manifests itself as delayed and slow puberty. IGFALS mutations have also been associated with insulin resistance. Mature IGFALS protein is composed of 578 amino acids with 20 leucine-rich repeats. It shares 93% identity between mouse and rat, and 79% between mouse and human.
Size10 µg
Concentrationn/a
ApplicationsBA
Other NamesACLSD, ALS, insulin-like growth factor binding protein, acid labile subunit
Gene, Accession, CAS #Gene ID: 4192
Catalog #758802
Price
Order / More InfoRecombinant Human IGFALS (carrier-free) from BIOLEGEND
Product Specific Referencesn/a
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