Mechanotransduction across the cell surface and through the cytoskeleton
- PMID: 7684161
- DOI: 10.1126/science.7684161
Mechanotransduction across the cell surface and through the cytoskeleton
Abstract
Mechanical stresses were applied directly to cell surface receptors with a magnetic twisting device. The extracellular matrix receptor, integrin beta 1, induced focal adhesion formation and supported a force-dependent stiffening response, whereas nonadhesion receptors did not. The cytoskeletal stiffness (ratio of stress to strain) increased in direct proportion to the applied stress and required intact microtubules and intermediate filaments as well as microfilaments. Tensegrity models that incorporate mechanically interdependent struts and strings that reorient globally in response to a localized stress mimicked this response. These results suggest that integrins act as mechanoreceptors and transmit mechanical signals to the cytoskeleton. Mechanotransduction, in turn, may be mediated simultaneously at multiple locations inside the cell through force-induced rearrangements within a tensionally integrated cytoskeleton.
Comment in
-
A new twist on integrins and the cytoskeleton.Science. 1993 May 21;260(5111):1080-1. doi: 10.1126/science.8493551. Science. 1993. PMID: 8493551 No abstract available.
Similar articles
-
Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension.Biophys J. 1994 Jun;66(6):2181-9. doi: 10.1016/S0006-3495(94)81014-8. Biophys J. 1994. PMID: 8075352 Free PMC article.
-
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure.Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):849-54. doi: 10.1073/pnas.94.3.849. Proc Natl Acad Sci U S A. 1997. PMID: 9023345 Free PMC article.
-
Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry.Biochem Cell Biol. 1995 Jul-Aug;73(7-8):327-35. doi: 10.1139/o95-041. Biochem Cell Biol. 1995. PMID: 8703406
-
Integrins, tensegrity, and mechanotransduction.Gravit Space Biol Bull. 1997 Jun;10(2):49-55. Gravit Space Biol Bull. 1997. PMID: 11540119 Review.
-
Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology.Circ Res. 2002 Nov 15;91(10):877-87. doi: 10.1161/01.res.0000039537.73816.e5. Circ Res. 2002. PMID: 12433832 Review.
Cited by 726 articles
-
Stick, stretch, and scan imaging method for DNA and filaments.RSC Adv. 2021 Nov 9;11(57):36060-36065. doi: 10.1039/d1ra07067c. eCollection 2021 Nov 4. RSC Adv. 2021. PMID: 35492749 Free PMC article.
-
Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP.Nat Commun. 2022 Mar 4;13(1):1174. doi: 10.1038/s41467-022-28693-y. Nat Commun. 2022. PMID: 35246520 Free PMC article.
-
The Alleviating Effect of Lagerstroemia indica Flower Extract on Stretch Marks through Regulation of Mast Cells.Molecules. 2022 Feb 14;27(4):1274. doi: 10.3390/molecules27041274. Molecules. 2022. PMID: 35209065 Free PMC article.
-
Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D.Adv Sci (Weinh). 2022 Apr;9(12):e2105325. doi: 10.1002/advs.202105325. Epub 2022 Feb 20. Adv Sci (Weinh). 2022. PMID: 35187856 Free PMC article.
-
Molecular Tension Probes to Quantify Cell-Generated Mechanical Forces.Mol Cells. 2022 Jan 31;45(1):26-32. doi: 10.14348/molcells.2022.2049. Mol Cells. 2022. PMID: 35114645 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
