| 产品详情 |
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| Product Name | AT-13148 |
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| Description | An orally bioavailable and ATP-competitive multi-AGC kinase inhibitor; inhibits Akt1, 2, and 3 (IC50s = 38, 402, and 50 nM, respectively); inhibits p70S6K, PKA, and ROCK-I and ROCK-II (IC50s = 3-8 nM); antiproliferative against cancer cell lines with genetic mutations in PI3K-Akt-mTOR or RAS-RAF pathways (GI50s = 1.54-3.77 µM); inhibits growth of MES-SA uterine sarcoma and BT474 breast cancer xenografts in mice (50 mg/kg, p.o.); inhibits ROCK-dependent phosphorylation of MLC2 over a 24-hour period in 4599 mouse melanoma cells (EC50 = 0.1 µM); reduces motility of 4699 melanoma cells in murine xenograft model |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AT13148 Akt2 Akt3 ROCK-1 ROCK1 ROCK2 BT-474 MLC-2 anti-proliferative ROCKI ROCKII |
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| Gene, Accession, CAS # | CAS: 1056901-62-2 |
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| Catalog # | 21597-1 |
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| Price | |
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| Order / More Info | AT-13148 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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