| 产品详情 |
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| Antigenic Specificity | CD117 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human, monkey, cow |
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| Isotype | IgG1 |
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| Format | phycoerythrin (PE) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells. Although CD117 is primarily a marker for non-lymphoid progenitor, it has been reported to be detected on early lymphoid progenitor. CD117 expression has been found on a small subset of resting NK cells (CD56 bright), and about 30% of immature CD3-/CD4-/CD8- thymocytes. CD117 is also expressed on mast cells and detected on non-hematopoietic cells such as reproductive system, melanocytes and embryonic brain. |
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| Immunogen | MOLM-1 megakaryocytic cell line. |
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| Other Names | CD117; Stem cell factor receptor; c-kit; mast cell growth factor receptor; steel factor receptor; SCF-R; Rat anti Mouse CD117; KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT; SCFR; mast/stem cell growth factor receptor Kit; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; soluble KIT varian; Tyrosine-protein kinase Kit; CD antigen CD117 |
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| Gene, Accession # | Gene ID: 3815, SwissProt: P10721 |
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| Catalog # | abx200489 |
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| Price | |
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| Order / More Info | CD117 Antibody from ABBEXA |
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| Product Specific References | n/a |
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