| 产品详情 |
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| Antigenic Specificity | NO66 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:45 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NO66 Polyclonal Antibody. Histone demethylase that specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. |
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| Immunogen | n/a |
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| Other Names | MAPJD; NO66; MYC-associated protein with JmjC domain; hsNO66; lysine-specific demethylase NO66; nucleolar protein 66 |
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| Gene, Accession # | Entrez: 314300, 71952, 79697; Uniprot: D3ZU57, Q9H6W3, Q9JJF3 |
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| Catalog # | PA5-67597 |
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| Price | |
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| Order / More Info | NO66 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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