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Antigenic Specificity | Caspase 8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | purified |
Size | 100 µL |
Concentration | n/a |
Applications | Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:500-1:3000 |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Caspase 8 Polyclonal Antibody. Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases play a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 was detect |
Immunogen | n/a |
Other Names | ALPS2B, CAP4, Casp-8, FLICE, FLJ17672, MACH, MCH5, MGC78473, CASP8, MORT1-associated ced-3 homolog, caspase-8, FADD-like ICE, MACH-beta-1/2/3/4 protein, ICE-like apoptotic protease 5, apoptotic cysteine protease, FADD-homologous ICE/CED-3-like protease, MACH-alpha-1/2/3 protein, caspase 8, apoptosis-related cysteine protease , apoptotic protease Mch-5, caspase 8, apoptosis-related cysteine peptidase |
Gene, Accession # | Entrez: 12370, 64044, 841; Uniprot: O89110, Q14790, Q9JHX4 |
Catalog # | PA5-77888 |
Price | |
Order / More Info | Caspase 8 Antibody from INVITROGEN ANTIBODIES |
Product Specific References | n/a |
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