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Product Name | SLC5111312 (hydrochloride) |
Description | A dual SPHK1 and SPHK2 inhibitor (Kis = 0.73 and 0.9 µM, respectively, using human recombinant kinases); selective for Sphk2 over Sphk1 in mice (Kis = 1 and 20 µM, respectively); not selective in rat (Kis = 1.1 and 0.8 µM for Sphk2 and Sphk1, respectively); decreases S1P in vitro at concentrations of 0.1 and 0.3 µM; decreases S1P in Sphk1-/- knockout mice and in rat at a dose of 10 mg/kg |
Size | 500 µg |
Concentration | n/a |
Applications | n/a |
Other Names | 1870811-00-9 SPHK-1 2 SLC-5111312 U-937 SLC-5111312 |
Gene, Accession, CAS # | CAS: 1870811-01-0 |
Catalog # | 23288-500 |
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Order / More Info | SLC5111312 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |
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