| 产品详情 |
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| Antigenic Specificity | CD117 (c-Kit) |
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| Clone | 2B8 |
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| Host Species | Rat |
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| Reactive Species | mouse, porcine |
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| Isotype | IgG2b, kappa |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.125 µg/test |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD117 (c-Kit) Monoclonal Antibody (2B8), APC, eBioscience™. c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activa |
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| Immunogen | n/a |
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| Other Names | C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit |
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| Gene, Accession # | Entrez: 16590, 396810; Uniprot: P05532, Q2HWD6 |
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| Catalog # | 17-1171-83 |
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| Price | |
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| Order / More Info | CD117 (c-Kit) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 16418395, 16533754, 17030619, 17079688, 17090683, 17881510, 18003603, 18566404, 18784839, 19020663, 19182774, 19200802, 19277590, 19395555, 19494337, 19797526, 19843942, 19843951, 20303345, 20519647, 20708017, 20966168, 21038084, 21149601, 21190992, 21248142, 21364283, 21398616, 21421850, 21494550, 21515822, 21624619, 21680798, 21687602, 21725055, 21738467, 21826372, 21946417, 21948176, 21963833, 21989919, 22101896, 22290850, 22323481, 22363661, 22422820, 22496586, 22531781, 22585451, 22628281, 22778389, 22854708, 23056333, 23185234, 23241885, 23396050, 23544085, 23563238, 23626777, 23630390, 23708211, 23736699, 23863713, 23993099, 24046360, 24091730, 24177428, 24184560, 24390425, 24494704, 24616378, 24722830, 25143383, 25225459, 25597017, 25627671, 25824689, 25840412, 25866967, 25979706, 26046579, 26083390, 26086617, 26183432, 26214128, 26258444, 26387756, 26416744, 26477271, 26519535, 26569382, 26601269, 26608918, 26634606, 26830229, 26923823, 26929198, 26937964, 26952187, 26979597, 27010503, 27054330, 27106930, 27113195, 27123834, 27338355, 27886239, 27902770, 27941791, 27984734, 27991919, 28024152, 28115023, 28292847, 28330582, 28399410, 28479304, 28875933, 28963568, 28973433, 29391748, 29555020, 29625072 |
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