| 产品详情 |
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| Antigenic Specificity | RUVBL1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB, IHC, FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1 CTNNB1 complex. High levels of autoantibodies against RUVBL1 are detected in sera of patients with autoimmune diseases such as polymyositis/dermatomyosistis and autoimmune hepatitis. This RUVBL1 (TIP49) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-280 amino acids from the Central region of human RUVBL1 (TIP49). |
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| Immunogen | Human RUVBL1. |
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| Other Names | RUVBL1; RuvB Like AAA ATPase 1; INO80 Complex Subunit H; 49 KDa TATA Box-Binding Protein-Interacting Protein; 54 KDa Erythrocyte Cytosolic Protein; TIP60-Associated Protein 54-Alpha; 49 KDa TBP-Interacting Protein; RuvB (E Coli Homolog)-Like 1; Nuclear Matrix Protein 238; RuvB-Like AAA ATPase; TAP54-Alpha; Pontin 52; NMP 238; Pontin; ECP-54; INO80H; NMP238; TIP49A; TIP49; TATA Binding Protein Interacting Protein 49 kDa; RuvB-Like AAA ATPase 1; RuvB-Like 1 (E. Coli); RuvB-Like 1; Pontin52; ECP54; TIH1; RVB1 |
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| Gene, Accession # | SwissProt: Q9Y265 |
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| Catalog # | abx030866 |
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| Price | |
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| Order / More Info | RUVBL1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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| 产品资料 |
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