| 产品详情 |
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| Product Name | Pirfenidone |
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| Description | An orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities; inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner; inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 at 300 mg/kg in lung in a mouse model of pulmonary fibrosis induced by bleomycin; inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 in a mouse model of NASH at 280 mg/kg; inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively) |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AMR 69 |
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| Gene, Accession, CAS # | CAS: 53179-13-8 |
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| Catalog # | 13986-50 |
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| Order / More Info | Pirfenidone from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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