| 产品详情 |
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| Product Name | TPX-0005 |
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| Description | A multi-kinase inhibitor; inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as ROS1 (IC50 = 0.07 nM); inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively); inhibits proliferation of PC-9, H1975, 11-18, HCC4006, and HCC827 cells (IC50s = 100, 100, 150, 148, and 430 nM, respectively) with additive or synergistic effects when used in combination with certain compounds, including osimertinib; reduces tumor growth in PC-9 and H1975 mouse xenograft models; potentiates the effect of osimertinib on tumor growth in vivo |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TPX0005 Trk-A B C Cros ROS-1 JAK-2 PC9 H-1975 1118 HCC-4006 HCC-827 |
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| Gene, Accession, CAS # | CAS: 1802220-02-5 |
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| Catalog # | 23397-10 |
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| Price | |
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| Order / More Info | TPX-0005 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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