| 产品详情 |
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| Product Name | SH-4-54 |
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| Description | A STAT3 inhibitor (IC50 = 4.7 µM for STAT3 homodimer DNA binding activity); selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5; decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells; inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 µM, respectively); inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models at 3 mg/kg per day |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SH454 STAT 1 3 5 MB231 U251 MG SH4 54 SH 454 NIH 3T3 Bcl2 MDAMB231 |
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| Gene, Accession, CAS # | CAS: 1456632-40-8 |
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| Catalog # | 25982-25 |
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| Price | |
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| Order / More Info | SH-4-54 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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