| 产品详情 |
| Edit |   |
|---|
| Product Name | VU0467154 |
|---|
| Description | A positive allosteric modulator of the M4 muscarinic acetylcholine receptor; potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively); selective for M4 over M1-3 and M5 receptors and a panel of receptors, transporters, and cation channels at 10 µM; reverses amphetamine-induced hyperlocomotion in rats from 3-56.6 mg/kg; reverses MK-801-induced hyperlocomotion, deficits in a pairwise visual discrimination task, and impairments in the acquisition of contextual fear conditioning in wild-type mice; increases freezing behavior in contextual and tone fear conditioning tests in wild-type mice when administered prior to the conditioning session from 3-30 mg/kg; reduces motor incoordination and prevents decreases in locomotion in the YAC128 transgenic mouse model of Huntington's disease at 10 mg/kg |
|---|
| Size | 25 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | VU-0467154 M2 M3 MK801 YAC-128 |
|---|
| Gene, Accession, CAS # | CAS: 1451993-15-9 |
|---|
| Catalog # | 25555-25 |
|---|
| Price | |
|---|
| Order / More Info | VU0467154 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|