| 产品详情 |
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| Antigenic Specificity | Diphtheria Toxin A |
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| Clone | 8A4 |
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| Host Species | Mouse |
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| Reactive Species | n/a |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: 1:100-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Diphtheria Toxin A Monoclonal Antibody (8A4). Diphtheria toxin is a 58 kDa protein secreted by lysogenic strains of Corynebacterium diphtheriae. The toxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis. The mechanism of inhibition involves transfer of the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. The catalysed reaction is as follows: NAD + + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide The crystal structure of the diphtheria toxin homodimer has been determined to 2.5A resolution. The structure reveals a Y-shaped molecule of 3 domains, a catalytic domain (fragment A), whose fold is of the alpha + beta type; a |
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| Immunogen | n/a |
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| Other Names | DT; DTA |
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| Gene, Accession # | n/a |
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| Catalog # | MA1-46398 |
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| Price | |
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| Order / More Info | Diphtheria Toxin A Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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