| 产品详情 |
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| Antigenic Specificity | c-Kit |
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| Clone | 2B8 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b, kappa |
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| Format | APC-Cyanine7 conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.2 µg/1x10^6 cells |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | c-Kit Monoclonal Antibody (2B8), APC-Cyanine7. c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf |
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| Immunogen | n/a |
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| Other Names | C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit |
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| Gene, Accession # | Entrez: 16590; Uniprot: P05532 |
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| Catalog # | A15423 |
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| Price | |
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| Order / More Info | c-Kit Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 25870111, 28004388 |
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