| 产品详情 |
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| Product Name | SCH 529074 |
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| Description | An activator of p53; restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay (Kds = 0.6740 and 0.4313, respectively); stimulates DNA binding activity and prevents Hdm-2 ubiquitination of wild-type p53 in vitro; reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM); reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | p-53 oncogenic HDM2 anti-tumor antitumor SCH529074 DLD1 |
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| Gene, Accession, CAS # | CAS: 922150-11-6 |
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| Catalog # | 21552-10 |
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| Price | |
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| Order / More Info | SCH 529074 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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