| 产品详情 |
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| Antigenic Specificity | RSPO1 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | ascites |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA, WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | R-Spondin 1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF beta pathway. Has a essential roles in ovary determination. |
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| Immunogen | Purified recombinant fragment of R-spondin1 expressed in E. Coli. |
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| Other Names | Roof plate-specific spondin-1; hRspo1; RSPO1; CRISTIN3; FLJ40906; R-Spondin 1; RSPONDIN |
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| Gene, Accession # | RSPO1, Gene ID: 284654, SwissProt: Q2MKA7 |
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| Catalog # | abx011430 |
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| Price | |
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| Order / More Info | RSPO1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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