| 产品详情 |
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| Product Name | Nebivolol (hydrochloride) |
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| Description | A potent and selective β1-AR antagonist (IC50s = 7.41 and 251 nM for β1- and β2-ARs, respectively in a radioligand binding assay using rabbit lung membrane preparations); selective for β1-ARs over 5-HT1A and 5-HT2, α1- and α2-adrenergic, H1, and D2 receptors (IC50s = 27.5 and 2,239, 3,162 and >10,000, 5,623, and 10,000 nM, respectively); inhibits cAMP accumulation induced by norepinephrine in primary rat cardiac cells (IC50 = 22 nM); induces vasodilation in mouse renal arteries via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 µM); decreases contraction of isolated human left ventricular trabeculae induced by isoproterenol (IC50 = 7.0 µM) but does not exert ISA; inhibits proliferation of HCASMCs in the presence and absence of growth factors (IC50s = 6.1, 6.8, 6.4, and 7.7 µM for HCASMCs grown in media containing no growth factor, PDGFBB, basic FGF, and TGF-β1, respectively), |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 118457-14-0 R067555 Nebicard Nebilet Nodon β1AR β2AR 5HT 5HT1A 5HT2 TGFβ1 R-067555 NO platelet-derived transforming fibroblast PDGF-BB |
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| Gene, Accession, CAS # | CAS: 152520-56-4 |
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| Catalog # | 23660-10 |
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| Order / More Info | Nebivolol (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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