| 产品详情 |
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| Product Name | PRIMA-1 |
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| Description | Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism. |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DNA binding anti-oncogenic apoptosis cancer p53 re-activator reactivator induces apoptotic re-activation reactivation antioncogenic cancers 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
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| Gene, Accession, CAS # | CAS: 5608-24-2 |
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| Catalog # | 63520-10 |
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| Order / More Info | PRIMA-1 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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