| 产品详情 |
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| Product Name | Hesperadin |
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| Description | A multi-kinase inhibitor; inhibits human Aurora kinase B (IC50 = 250 nM) and the T. brucei homolog Aurora kinase-1 (IC50 = 40 nM); inhibits AMPK, LCK, MKK1, MAPKAP-K1, CHK1, and PHK in a panel of 25 kinases at 1 µM; inhibits MEKK2 in ATPase and transphosphorylation assays (IC50s = 60 and 34 nM, respectively); induces polyploidy and defects in cytokinesis and spindle assembly as well as inhibits proliferation of HeLa cells and overrides paclitaxel- and monastrol-induced mitotic arrest from 50-100 nM; induces toxicity in HepG2 cells (TC50 = 50 = 0.22-2.21 µM); inhibits the growth of T. brucei, L. major promastigotes and amasigotes, and P. falciparum (EC50s = 0.01-2.37 µM), |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Hesperadine Trypanosoma MKK-1 MAPKAPK1 CHK-1 MEKK-2 Hep-G2 Leishmania Plasmodium |
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| Gene, Accession, CAS # | CAS: 422513-13-1 |
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| Catalog # | 24199-10 |
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| Price | |
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| Order / More Info | Hesperadin from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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