| 产品详情 |
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| Antigenic Specificity | PSMB8 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human, rat |
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| Isotype | IgG1 |
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| Format | ascites |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA, WB, IHC, IF/ICC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. |
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| Immunogen | Purified recombinant fragment of human PSMB8 expressed in E. Coli. |
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| Other Names | JMP; ALDD; LMP7; NKJO; D6S216; PSMB5i; RING10; D6S216E; MGC1491; Y2; Proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i; Really interesting new gene 10 protein; proteasome (prosome; macropain) subunit; beta type; 8 (large multifunctional peptidase 7); PSMB8; beta5i; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); OTTHUMP00000029420; OTTHUMP00000029421; OTTHUMP00000062981; low molecular weight protein 7; macropain |
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| Gene, Accession # | Gene ID: 5696, SwissProt: P28062 |
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| Catalog # | abx011689 |
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| Price | |
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| Order / More Info | PSMB8 Antibody from ABBEXA |
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| Product Specific References | n/a |
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