| 产品详情 |
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| Antigenic Specificity | SIGLEC6 |
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| Clone | polyclonal |
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| Host Species | Goat |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | peptide-ELISA: 1:16000, Western Blot: 0.5-1.5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SIGLEC6 Polyclonal Antibody. SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. |
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| Immunogen | n/a |
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| Other Names | Sialic acid binding Ig-like lectin 6, Obesity-binding protein 1, OB-BP1, CD33 antigen-like 1, CD33L |
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| Gene, Accession # | Entrez: 946; Uniprot: O43699 |
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| Catalog # | PA5-19357 |
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| Price | |
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| Order / More Info | SIGLEC6 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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