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| Antigenic Specificity | RAF1 (pS621) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µl, 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB, IF/ICC, IP. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RAF1 (pS621) Antibody is a Rabbit Polyclonal antibody against RAF1 (pS621). This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. |
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| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S621 of human RAF1. |
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| Other Names | C-RAF; CRAF; Protein kinase raf 1; RAF proto-oncogene serine/threonine-protein kinase; RAF-1; RAF1; Similar to murine leukemia viral (V-raf-1) oncogene homolog 1; kinase Raf1; NS5; Proto-oncogene c-RAF; RAF |
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| Gene, Accession # | RAF1, Gene ID: 5894, SwissProt: P04049 |
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| Catalog # | abx000159 |
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| Price | |
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| Order / More Info | RAF1 (pS621) Antibody from ABBEXA |
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| Product Specific References | n/a |
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