产品名称 TLR10 Antibody from DENDRITICS SAS
产品货号 DDX0490
产品价格 现货询价,电话:010-67529703
产品规格 100µg/50µg
产品品牌 DENDRITICS SAS
产品概述
产品详情
Edit&nbsp
Antigenic SpecificityTLR10
Clone25F9
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatpurified
Size100µg/50µg
Concentrationn/a
ApplicationsFACS on transfected cells, IHC
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe Toll-Like Receptors (TLR) is a family of germline-encoded proteins, composed of C-terminal leucine-rich repeats (LRR), and an N-terminal Toll/Interleukin-1 Receptor (TIR) domain (1). In humans, 10 TLRs, sharing high sequence homology, have been identified. TLRs are critical for the detection of pathogen-associated molecular patterns (PAMPs) by the innate immune system. LRR recognize PAMPs, and signal transduction events, initiated by the TIR domain, lead to activation of the transcription factors such as AP-1, IRFs and NFkB, and therefore expression of proinflammatory cytokines and costimulatory molecules.. TLR9 mRNA is detected in spleen, lymph nodes, bone marrow and PBLs (6, 7).Human TLR10 is an orphan member of the TLR family. Genomic studies indicate that TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2. (Akira, S et al, Nat Rev Immunol ,2004 4:499-511 ; Flacher V et al, J.Immunol, 2006,177, 959-67 ; Hasan U et al, J.Immunol, 2005, 174, 2942-50)
Immunogenn/a
Other NamesToll-like receptor 10
Gene, Accession #n/a
Catalog #DDX0490
Price
Order / More InfoTLR10 Antibody from DENDRITICS SAS
Product Specific Referencesn/a
产品资料