| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | HIV-1 gp41 |
|---|
| Clone | 425D11.01 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 100µg/50µg |
|---|
| Concentration | n/a |
|---|
| Applications | Flow cytometry, Neutralization, Cell-coated ELISA, Inhibition of syncitia formation, Blocking of HR1/HR2 complex formation |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | HIV-1-gp41 is a subunit of the envelope protein complex of HIV. HIV-1-gp41 is responsible for the fusion between the viral and the cell membranes and thus represents a target for HIV vaccines. Trimeric Env is composed of gp120, which is non-covalently associated with the membrane-anchored fusion protein gp41. HIV-1 gp120 binding to CD4 and co-receptor (CCR5 or CXCR4) induces conformational changes, resulting in gp41 exposure and in the production of fusion-intermediate conformation of gp41 (HR1 and HR2). 3 neutralizing anti-gp41 monoclonal antibodies were selected from mice immunized with 293T cells stably transfected with a construct expressing HR1 plus HR2. (Dawood R et al, AIDS. 27(5):717-730, 2013). |
|---|
| Immunogen | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | DDX1306 |
|---|
| Price | |
|---|
| Order / More Info | HIV-1 gp41 Antibody from DENDRITICS SAS |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|