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| Product Name | JMJD6, 1-414aa, Human, His tag, E.coli |
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| Description | Purity: > 90% by SDS - PAGE Format: Liquid, In Phosphate buffered saline (pH7.4) containing 30% glycerol, 1mM DTT. JMJD6 also known as bifunctional arginine demethylase and lysyl-hydroxylase JMJD6. JMJD6 acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2AF2/u2AF65 and LuC7L2, as a regulator of RNA splicing by mediating 5-hydroxylation of u2AF2/u2AF65, affecting the pre-mRNA splicing activity of u2AF2/u2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. Recombinant human JMJD6, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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| Size | 250ug, 50ug, 10ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform1, PSR, PTDSR, PTDSR1 |
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| Gene, Accession, CAS # | NP 001074930 |
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| Catalog # | ATGP2999 |
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| Order / More Info | JMJD6, 1-414aa, Human, His tag, E.coli from ATGen |
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| Product Specific References | n/a |
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