| 产品详情 |
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| Antigenic Specificity | TICAM1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA, WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TICAM1 Antibody is a Rabbit Polyclonal antibody against TICAM1. Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responsesTLRs recognize conserved motifs found in various pathogens and mediate defense responsesTriggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genesThe TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domainUpon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule)This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKKActivation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasmTRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-κB, IRF3 and trigger IFN-β productionStudies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectivelyTRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-κB activationIn addition, TRIF can trigger signaling of that lead to the induction of apoptosis. |
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| Immunogen | Recombinant protein of human TICAM1. |
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| Other Names | TICAM1; PRVTIRB; TRIF; TIR domain-containing adapter molecule 1; Proline-rich; vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; TICAM-1 |
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| Gene, Accession # | TICAM1, Gene ID: 148022, SwissProt: Q8IUC6 |
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| Catalog # | abx117043 |
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| Price | |
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| Order / More Info | TICAM1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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