| 产品详情 |
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| Antigenic Specificity | FAK |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FAK Polyclonal Antibody. Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. Tyrosine 397 is the autophosphorylation site of FAK, and involved in its initial activation. This phosphorylated site binds Src family SH2 domains and the p85 subunit of PI3-Kinase, and activates cell migration and invasion. FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. |
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| Immunogen | n/a |
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| Other Names | EC 2.7.10.2, FADK 1, FAK1, Focal adhesion kinase 1, PTK2, Protein- tyrosine kinase 2, pp125FAK |
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| Gene, Accession # | Entrez: 14083, 25614, 5747; Uniprot: O35346, P34152, Q05397 |
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| Catalog # | AHO0502 |
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| Price | |
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| Order / More Info | FAK Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 16927379, 17081517, 18206871, 18228476, 18382676, 20101206, 21152434, 21525268, 22149259, 22172030, 22989880, 23606749, 23637231, 25594017, 26681405, 26728244, 29050309 |
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