| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | CD45 |
|---|
| Clone | monoclonal |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | ascites |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA, WB, IHC. RUO |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | CD45, also known as TPRC (protein tyrosine phosphatase, receptor type, C). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. |
|---|
| Immunogen | Purified recombinant fragment of CD45 expressed in E. Coli. |
|---|
| Other Names | CD45; B220; CD45R; CD45RA; CD45RB; CD45RC; CD45RO; LCA; T200; Ly5; Leukocyte common antigen; L-CA; MAB TO CD45; Leukocyte Common Antigen (LCA); Receptor-type tyrosine-protein phosphatase C; CD antigen CD45; GP180; PTPRC |
|---|
| Gene, Accession # | PTPRC, Gene ID: 5788, SwissProt: P08575 |
|---|
| Catalog # | abx010527 |
|---|
| Price | |
|---|
| Order / More Info | CD45 Antibody from ABBEXA |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|