产品名称 Glial Fibrillary Acidic Protein (GFAP) (intact) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN94316
产品价格 现货询价,电话:010-67529703
产品规格 0.1 mg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityGlial Fibrillary Acidic Protein (GFAP) (intact)
CloneGF-02
Host SpeciesMouse
Reactive Specieshuman, porcine
IsotypeIgM
Formatascites
Size0.1 mg
Concentrationn/a
ApplicationsImmunocytochemistry (ICC),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunohistochemistry (Frozen Sections) (IHC (fro)),Western Blotting (WB)
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DescriptionGlial Fibrillary Acidic Protein (GFAP) was discovered by Bignami et al. (1972) as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10 nm or intermediate filament protein family, specifically the intermediate filament protein family Class III, which also includes peripherin, desmin and vimentin. GFAP is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. It is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. Although its function is not fully understood, GFAP protein is probably involved in controlling the shape and movement of astrocytes. The protein probably also plays a significant role in the interactions of astrocytes with other cells, which are required for the formation and maintenance of the insulating layer (myelin) that covers nerve cells. Additionally, GFAP protein may assist in maintaining the protective barrier that allows only certain substances to pass between blood vessels and the brain (blood-brain barrier).In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer’,s disease, epilepsy and multiple sclerosis.Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells and for distinguishing of neoplasms of astrocytic origin from other neoplasms in the central nervous system. Finally, Alexander's disease was recently shown to be caused by point mutations in protein coding region of the GFAP gene (Brenner et al., 2001). All forms of Alexander disease are characterized by the presence of Rosenthal fibers, which are GFAP containing cytoplasmic inclusions found in astrocytes.
ImmunogenPellet of porcine brain cold-stable proteins after depolymerization of microtubules.
Other NamesGFAP|AI836096|cb345|etID36982.3|gfapl|wu:fb34h11|wu:fk42c12|xx:af506734|zgc:110485
Gene, Accession #Gene ID: 2670,396562
Catalog #ABIN94316
Price
Order / More InfoGlial Fibrillary Acidic Protein (GFAP) (intact) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 12923773
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