| 产品详情 |
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| Product Name | AV 412 |
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| Description | Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases (IC50 values are 0.5-2, 19 and 41 nM, respectively). Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCLC and T-47D breast cancer cell lines, respectively. Inhibits tumor growth of EGFR-overexpressing A431 and ErbB2 overexpressing BT-474 tumor xenografts in mice. Purity 98%. MW (observed): 507 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide |
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| Gene, Accession, CAS # | CAS: 451492-95-8 |
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| Catalog # | 4397/10 |
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| Price | |
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| Order / More Info | AV 412 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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