| 产品详情 |
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| Product Name | SR 48692 |
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| Description | An allosteric antagonist of NTS1 (Kd = 3.4 nM); inhibits neurotensin binding to brain tissue from guinea pig, newborn mouse, newborn human, and adult human as well as rat mesencephalic cells and HT-29 cells (IC50s = 0.99-30.3 nM); blocks neurotensin induced intracellular calcium mobilization in HT-29 cells (Ki = 7.4 nM); reduces tumor volume and cell proliferation in an NCI-H209 mouse xenograft model (10 µg per day); reduces contralateral turning induced by neurotensin administration in mice by 85% (80 µg/kg, p.o.); delays sensitization to the locomotor activating effects of cocaine in rats when administered prior to cocaine delivery and not concomitantly |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Meclinertant SR48692 NTS-1 HT29 NCIH209 NCIH345 |
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| Gene, Accession, CAS # | CAS: 146362-70-1 |
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| Catalog # | 20124-10 |
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| Order / More Info | SR 48692 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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