| 产品详情 |
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| Antigenic Specificity | DNMT1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Western Blot: 2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DNMT1 Polyclonal Antibody. DNA methyltransferases (Dnmts) methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, genetic imprinting, and X-chromosome inactivation. Hypermethylation of DNA has been implicated in tumorigenesis through improper methylation of growth regulatory gene promoter regions. There exist three isoforms of Dnmts, Dnmt1, 2 and 3. Dnmt1 is believed to perform most of the maintenance and de novo methylation activities that occur in somatic cells of mammals. Studies have shown that Dnmt1 can establish repression of transcription complexes consisting of Dnmt1, histone deacetylase 2 (HDAC2), and DNA methyltransferase 1 associated protein (DMAP1). T |
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| Immunogen | n/a |
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| Other Names | Dnmt1 |
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| Gene, Accession # | Entrez: 1786, 84350; Uniprot: P26358, Q9Z330 |
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| Catalog # | PA1-880 |
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| Price | |
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| Order / More Info | DNMT1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 11063128 |
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| 产品资料 |
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