| 产品详情 |
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| Antigenic Specificity | DNMT1 |
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| Clone | 60B1220.1 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, porcine, rat |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | ChIP assay: 1:10-1:500, Immunocytochemistry: 1:10, Immunofluorescence: Assay-Dependent, Immunohistochemistry - Free Floating: 1:500, Immunohistochemistry (Frozen): 1:500, Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 1:10-1:500, Western Blot: 0.1-0.5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DNMT1 Monoclonal Antibody (60B1220.1). Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Th |
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| Immunogen | n/a |
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| Other Names | AIM, CXXC9, DNMT, HSN1E, MCMT, CXXC finger protein 9, CXXC-type zinc finger protein 9, DNA (cytosine-5)-methyltransferase 1, DNA MTase HsaI, DNA methyltransferase 1, DNA methyltransferase HsaI, m.HsaI |
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| Gene, Accession # | Entrez: 13433, 1786, 606746, 84350; Uniprot: P13864, P26358, Q9Z330 |
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| Catalog # | MA5-16169 |
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| Price | |
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| Order / More Info | DNMT1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 26815200 |
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