| 产品详情 |
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| Product Name | TAK-715 |
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| Description | An inhibitor of p38α MAPK (IC50 = 7.1 nM); selective for p38α over p38β (IC50 = 200 nM), as well as over p38γ/δ, JNK, ERK1, IKKβ, MEKK1, and TAK1 (IC50 = >10 µM for all) but also inhibits CK1δ and CK1ε; inhibits LPS-induced TNF-α release from THP-1 cells (IC50 = 48 nM); LPS-induced TNF-α production by 87.6% in mice at 10 mg/kg; reduces adjuvant-induced paw swelling in a rat model of rheumatoid arthritis at 30 mg/kg; inhibits Wnt3a-induced phosphorylation of hDvl2 in a p38α-independent manner |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | CAS: 303162-79-0 |
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| Catalog # | 26170-25 |
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| Price | |
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| Order / More Info | TAK-715 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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