| 产品详情 |
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| Product Name | P053 |
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| Description | An inhibitor of CerS1 (IC50s = 0.54 and 0.46 µM for human and mouse CerS1, respectively); selective for CerS1 over CerS2, CerS4, CerS5, and CerS6 (IC50s = 28.6, 17.2, 7.2, and 11.4 µM, respectively); lowers levels of C18 ceramide, C18 galactosylceramide, and C18:0 and 18:1 sphingomyelin species in HEK293 cells at 30-300 nM; decreases endogenous C18:1/18:0 and C18:2/18:0 ceramide levels in mouse skeletal muscle at 5 mg/kg; increases fatty acid oxidation in mouse skeletal muscle and inhibits triglyceride synthesis and increases in white adipose mass in a model of high-fat diet-induced obesity but does not affect insulin resistance |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | P-053 Cer-S1 S2 S4 S5 S6 CerS-1 2 4 5 6 C-18 18:2 22:0 24:0 24:1 C18:1 HEK-293 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 26113-500 |
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| Price | |
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| Order / More Info | P053 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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