| 产品详情 |
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| Product Name | AAT-008 |
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| Description | An orally bioavailable, potent, and selective EP4 receptor antagonist (IC50 = 16.3 nM in a human EP4 functional assay); selective for EP4, with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human EP4, EP2, EP1, and EP3, respectively; has potent binding affinity for human, rat, and dog EP4 (Kis = 0.97, 6.1, and 38 nM, respectively; suppresses PGE2-induced elevation of intracellular cAMP in vitro (pA2 = 1.1 nM); reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner, |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AAT008 EP-1 2 3 4 PGE-2 RQ-00000008 RQ00000008 PG-E2 |
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| Gene, Accession, CAS # | CAS: 847727-81-5 |
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| Catalog # | 21810-1 |
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| Order / More Info | AAT-008 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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