| 产品详情 |
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| Product Name | ARN14686 |
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| Description | An affinity probe for NAAA using click chemistry; inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells (IC50s = 6 and 13 nM for human and rat recombinant enzymes, respectively); selective for NAAA over acid ceramidase (IC50 = 1,200 nM for the rat enzyme); labels NAAA in HEK293 cells; labels NAAA in rat lung lysosomal fractions in vitro at 1 and 10 µM; detects NAAA in lung lysosomal fractions following a 10 mg/kg, i.v. dose in rats; has been used to determine that catalytically active NAAA is present in inflamed rat paw in a complete Freund's adjuvant model of inflammation at 3 mg/kg |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | Click Chemistry |
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| Other Names | ARN-14686 HEK-293 |
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| Gene, Accession, CAS # | CAS: 1628345-10-7 |
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| Catalog # | 24261-5 |
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| Price | |
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| Order / More Info | ARN14686 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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