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| Product Name | p53 Transcription Factor Assay Kit |
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| Description | The tumor suppressor protein p53 plays a crucial role in coordinating cellular responses to genotoxic stress and holds many important clinical implications in the treatment of cancer. Cayman's p53 Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific transcription factor DNA binding activity in nuclear extracts. A specific double-stranded DNA (dsDNA) sequence containing the p53 response element is immobilized onto the wells of a 96-well plate. p53 contained in a nuclear extract, binds specifically to the p53 response element and is detected by addition of a specific primary antibody directed against p53. A secondary antibody conjugated to HRP is added to provide a sensitive colorimetric readout at 450 nm. |
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| Size | 96 well |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | dsDNA double-stranded tumors suppressors proteins guardians of the genomes cells cellular responses genotoxic stresses activity cycles arrests apoptosis senescence humans cancers mutations inactivated binding ubiquitination acetylation phosphorylation sumoylation neddylation methylation glycosylation damages oncogenes ribosomal cell-matrix matrices adhesion hypoxia p21 WAF1 Cip1 MDM2 GADD45 Cyclin G Bax IGF-BP3 bcl-2 bcl-X cyclins B1 MAP4 survivin HPV16 PARP-1 WT1 E1b/E4 degradation nucleus cytoplasms proteasomes promoter carcinogenesis endogenous wild-type heterogenous autosomal dominant disorders Li Fraumeni Syndromes nuclear extracts ELISAs assays enzyme-linked immunosorbent TFs T.F. factors assays |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 600020-96WELLS |
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| Order / More Info | p53 Transcription Factor Assay Kit from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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