| 产品详情 |
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| Antigenic Specificity | SR-A, Mouse |
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| Clone | 2F8 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | frozen sections, FC, functional studies, IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody 2F8 recognizes mouse scavenger receptor class A (SR-A), type I and II, also known as CD204. SR-A belongs to the group of scavenger receptors, which are divided in class A, B, D and E. Class A scavenger receptors (SRs) are multi-domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. SR-A is expressed by tissue macrophages and functions both as an endocytic receptor for lipoproteins and as an adhesion receptor for macrophages binding to ligand rich tissues e.g. atherosclerotic lesions. Tissue macrophage- populations that express SR-A I and II include those of the marginal zone of the spleen, alveolar macrophages, heart and gut. SR-A binds bacterial pathogens and is considered to play a role in the innate immune response. TLR2 and TLR4 agonists synergistically up-regulate SR-A in RAW264.7 through p38 pathway. SR-A knockout mice are more susceptible to endotoxic shock than wild type mice, which suggests a role in the clearance of bacterial endotoxin from the circulation. Using thymic macrophages of the knockout mice as well as antibody treatment confirmed that SR-A is responsible for half of the phagocytic activity required for apoptotic thymocyte ingestion. Next to its role in innate immunity there is evidence that SR-A also contributes to acquired immune responses. Monoclonal antibody 2F8 recognizes an epitope within the αhelical coiled-coil domain of SR-A in all mouse strain tested, with the exception of C57BL/6. One amino-acid change (L168S), due to polymorphism, results in the loss of reactivity of antibody 2F8. |
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| Immunogen | RAW.264 cells (αhelical coiled coil domain CD204) |
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| Other Names | CD204 |
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| Gene, Accession # | n/a |
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| Catalog # | HM1061 |
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| Price | |
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| Order / More Info | SR-A, Mouse Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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